Cui Guihua, Guo Xiaoyu, Deng Li
Department of Chemistry, Jilin Medical University, Jilin, China.
Jilin Vocational College of Industry and Technology, Jilin, China.
Front Pharmacol. 2024 Aug 15;15:1439036. doi: 10.3389/fphar.2024.1439036. eCollection 2024.
Chitosan (CS) has been extensively studied in wound care for its intrinsic hemostatic and antibacterial properties. However, CS has limiting hemostasis applications on account of its drawbacks such as poor adhesion in humid environments and water solubility at neutral pH. CS-based biomaterials, inspired by mussel-adhesive proteins, serve as a suggested platform by biomedical science. The reports show that the mussel-inspired CS-based hemostatic structure has negligible toxicity and excellent adhesiveness. Biomedicine has witnessed significant progress in the development of these hemostatic materials. This review summarizes the methods for the modification of CS by mussel-inspired chemistry. Moreover, the general method for preparation of mussel-inspired CS-based biomaterials is briefly discussed in this review. This work is expected to give a better understanding of opportunities and challenges of the mussel-inspired strategy for the functionalization of CS-based biomaterials in hemostasis and wound healing. This review is hoped to provide an important perspective on the preparation of mussel-inspired CS-based hemostatic materials.
壳聚糖（CS）因其固有的止血和抗菌特性而在伤口护理领域得到了广泛研究。然而，由于其在潮湿环境中粘附性差以及在中性pH值下具有水溶性等缺点，CS的止血应用受到限制。受贻贝粘附蛋白启发的基于CS的生物材料，被生物医学科学视为一个推荐平台。报告显示，受贻贝启发的基于CS的止血结构毒性可忽略不计且具有出色的粘附性。生物医学在这些止血材料的开发方面取得了重大进展。本综述总结了通过受贻贝启发的化学方法对CS进行改性的方法。此外，本综述还简要讨论了制备受贻贝启发的基于CS的生物材料的一般方法。这项工作有望让人更好地理解受贻贝启发的策略在基于CS的生物材料止血和伤口愈合功能化方面的机遇与挑战。希望本综述能为制备受贻贝启发的基于CS的止血材料提供重要视角。
