Yang Yongfeng, Li Li, Chen Fei, Zhang Li, Bu Hong
1 Laboratory of Pathology, West China Hospital, Sichuan University, Key Laboratory of Transplant Engineering and Immunology, Sichuan University , Chengdu, China .
2 Laboratory of Pathology, Department of Pathology, West China Hospital, Sichuan University , Chengdu, Sichuan Province, China .
Genet Test Mol Biomarkers. 2018 May;22(5):314-319. doi: 10.1089/gtmb.2017.0256.
Interleukin-31 (IL-31), a novel T helper type 2 effector cytokine, is known to have an important effect on the pathogenesis of allergic disease and tumors. However, the impact of IL-31 on human lung cancer remains unclear.
This study explored the role of IL-31 polymorphisms in lung cancer and sought to characterize how IL-31 polymorphisms correlate with lung cancer tumorigenesis and patient survival rates. Using a single-nucleotide polymorphism genotype assay, we examined the expression of two IL-31 polymorphisms (rs7977932 and rs4758680) in samples from 302 lung cancer patients and 493 control cases.
Lung cancer patients who were homozygous CC for rs7977932 or carried the G allele of rs4758680 had significantly poorer prognoses compared to those who did not have these genotypes. Moreover, the rs7977932 CC genotype was significantly associated with metastasis and poor survival status in lung adenocarcinoma.
Our study indicates the importance of IL-31 polymorphisms for susceptibility and survival status in lung cancer.
白细胞介素-31（IL-31）是一种新型的2型辅助性T细胞效应细胞因子，已知其在过敏性疾病和肿瘤的发病机制中具有重要作用。然而，IL-31对人类肺癌的影响仍不清楚。
本研究探讨了IL-31基因多态性在肺癌中的作用，并试图阐明IL-31基因多态性与肺癌发生及患者生存率之间的关系。我们使用单核苷酸多态性基因型检测方法，检测了302例肺癌患者和493例对照样本中两种IL-31基因多态性（rs7977932和rs4758680）的表达情况。
与不具有这些基因型的患者相比，rs7977932为纯合子CC或携带rs4758680的G等位基因的肺癌患者预后明显较差。此外，rs7977932的CC基因型与肺腺癌的转移和不良生存状态显著相关。
我们的研究表明IL-31基因多态性对肺癌的易感性和生存状态具有重要意义。
