Wang Yanwen, Yang Yongfeng, Zhu Yihan, Li Li, Chen Fei, Zhang Li
a Laboratory of Pathology, Department of Pathology , West China Hospital Sichuan University , Chengdu , P.R. China.
Biomarkers. 2017 Mar;22(2):165-170. doi: 10.1080/1354750X.2016.1252956. Epub 2016 Nov 8.
Polymorphisms of IL-32 related closely to tumoregenesis.
Two IL-32 polymorphisms (rs12934561 and rs28372698) and mRNA expression were conducted by SNP genotype assay and real-time PCR in 423 lung cancer patients and 437 controls.
T allele of rs28372698 associated significantly with poor prognosis in moderate and well-differentiated lung cancer patients. TT genotype of rs12934561 related closely to poor survival status in squamous carcinoma. IL-32 mRNA expression decreased in lung cancer.
Our study indicates the importance of IL-32 polymorphism and mRNA expression in susceptibility and influence of survival status in lung cancer.
白细胞介素-32（IL-32）的多态性与肿瘤发生密切相关。
采用单核苷酸多态性（SNP）基因分型检测和实时定量聚合酶链反应（PCR），对423例肺癌患者和437例对照者检测两种IL-32多态性（rs12934561和rs28372698）及mRNA表达情况。
rs28372698的T等位基因与中高分化肺癌患者的预后不良显著相关。rs12934561的TT基因型与肺鳞癌患者的生存状态不佳密切相关。肺癌组织中IL-32 mRNA表达降低。
我们的研究表明IL-32多态性和mRNA表达在肺癌易感性及生存状态影响方面具有重要意义。
