Endocrine Cell Differentiation and Function Group, Stem Cell Centre, Lund University, Lund, Sweden.
Department of Clinical Sciences in Malmö, Unit of Molecular Metabolism, Lund University Diabetes Centre, Lund University, Malmö, Sweden.
Acta Physiol (Oxf). 2019 Jan;225(1):e13101. doi: 10.1111/apha.13101. Epub 2018 Jun 20.
The exact physiological role for the monoamine serotonin (5-HT) in modulation of insulin secretion is yet to be fully understood. Although the presence of this monoamine in islets of Langerhans is well established, it is only with recent advances that the complex signalling network in islets involving 5-HT is being unravelled. With more than fourteen different 5-HT receptors expressed in human islets and receptor-independent mechanisms in insulin-producing β-cells, our understanding of 5-HT's regulation of insulin secretion is increasing. It is now widely accepted that failure of the pancreatic β-cell to release sufficient amounts of insulin is the main cause of type 2 diabetes (T2D), an ongoing global epidemic. In this context, 5-HT signalling may be of importance. In fact, 5-HT may serve an essential role in regulating the release of insulin and glucagon, the two main hormones that control glucose and lipid homoeostasis. In this review, we will discuss past and current understanding of 5-HT's role in the endocrine pancreas.
血清素（5-HT）在调节胰岛素分泌方面的确切生理作用尚未完全阐明。尽管这种单胺在胰岛中已经得到充分证实，但直到最近，涉及 5-HT 的胰岛复杂信号网络才被揭示。在人类胰岛中表达的 5-HT 受体超过 14 种，以及胰岛素产生β细胞中的受体非依赖性机制，我们对 5-HT 调节胰岛素分泌的理解正在增加。现在人们普遍认为，胰岛β细胞不能释放足够量的胰岛素是 2 型糖尿病（T2D）的主要原因，这是一种正在持续蔓延的全球性疾病。在这种情况下，5-HT 信号可能很重要。事实上，5-HT 可能在调节胰岛素和胰高血糖素的释放中发挥重要作用，这两种主要的激素控制着葡萄糖和脂质的体内平衡。在这篇综述中，我们将讨论过去和现在对 5-HT 在胰岛中的作用的理解。
