Lancaster Charlene E, Ho Cheuk Y, Hipolito Victoria E B, Botelho Roberto J, Terebiznik Mauricio R
a Department of Biological Sciences, University of Toronto at Scarborough, Toronto, ON M1C 1A4, Canada.
b Department of Cell and System Biology, University of Toronto at Scarborough, Toronto, ON M1C 1A4, Canada.
Biochem Cell Biol. 2019 Feb;97(1):21-29. doi: 10.1139/bcb-2018-0008. Epub 2018 May 23.
Phagocytosis is an evolutionarily conserved process. In Protozoa, phagocytosis fulfills a feeding mechanism, while in Metazoa, phagocytosis diversified to play multiple organismal roles, including immune defence, tissue homeostasis, and remodeling. Accordingly, phagocytes display a high level of plasticity in their capacity to recognize, engulf, and process targets that differ in composition and morphology. Here, we review how phagocytosis adapts to its multiple roles and discuss in particular the effect of target morphology in phagocytic uptake and phagosome maturation.
吞噬作用是一个进化上保守的过程。在原生动物中，吞噬作用是一种进食机制，而在多细胞动物中，吞噬作用多样化以发挥多种机体作用，包括免疫防御、组织稳态和重塑。因此，吞噬细胞在识别、吞噬和处理成分及形态各异的靶标的能力方面表现出高度的可塑性。在这里，我们综述吞噬作用如何适应其多种作用，并特别讨论靶标形态对吞噬摄取和吞噬体成熟的影响。
