Allison M C, Pounder R E
Academic Department of Medicine, Royal Free Hospital, London, UK.
Aliment Pharmacol Ther. 1987 Feb;1(1):39-43. doi: 10.1111/j.1365-2036.1987.tb00604.x.
Eight patients with active uncomplicated Crohn's disease, who were resistant to or intolerant of conventional treatment, were treated for 6 weeks with oral cyclosporin (mean dose 8.2 mg kg-1 day-1). Seven of the eight patients responded to treatment with cyclosporin by symptomatic improvement, weight gain and a return of serum C-reactive protein concentration towards normal. All patients relapsed on stopping cyclosporin. No serious side-effects were encountered. This favourable early experience justifies further trials using cyclosporin for active Crohn's disease.
8例活动性非复杂性克罗恩病患者对传统治疗耐药或不耐受，接受口服环孢素治疗6周（平均剂量8.2毫克/千克/天）。8例患者中有7例经环孢素治疗后症状改善、体重增加且血清C反应蛋白浓度恢复正常。所有患者停用环孢素后均复发。未出现严重副作用。这一良好的早期经验证明进一步开展环孢素治疗活动性克罗恩病的试验是合理的。
