Division of Pulmonology, Department of Internal Medicine, Institute of Chest Disease, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 120-752, Republic of Korea.
Biostatistics Collaboration Unit, Department of Biomedical Systems Informatics, Yonsei University College of Medicine, Seoul, Republic of Korea.
Respir Res. 2018 May 23;19(1):99. doi: 10.1186/s12931-018-0814-z.
Bilirubin has been reported to be associated with respiratory diseases due to its antioxidant action. We aimed to evaluate the relationship between serum bilirubin concentration and annual lung function decline in the Korean general population.
The study included 7986 subjects aged 40-69 years from the Ansung-Ansan cohort database I (2001-2002)-III (2005-2006). We analyzed the relationships between serum bilirubin level and forced expiratory volume in 1 s (FEV), forced vital capacity (FVC), FEV/FVC, and mean forced expiratory flow between 25 and 75% of FVC (FEF) at baseline, as well as the annual average changes in these lung parameters.
The FEV, FVC, and FEF were significantly associated with serum bilirubin levels after adjustment for age, sex, body mass index (BMI), and smoking status (all P < 0.001). When stratified according to smoking status, these relationships were significant in never-smokers. Additionally, serum bilirubin level was negatively associated with the annual decline in FEV and FVC, and positively associated with the annual decline in FEV/FVC after adjustment for age, sex, BMI, baseline lung function, and smoking status (all P < 0.001).
We found significant associations of serum bilirubin levels with FEV, FVC, and FEF in the general population, especially in never-smokers. Moreover, serum bilirubin levels were related with the annual decline in FEV, FVC, and FEV/FVC ratio.
胆红素具有抗氧化作用，因此有研究报道其与呼吸系统疾病有关。我们旨在评估韩国一般人群血清胆红素浓度与年度肺功能下降之间的关系。
本研究纳入了来自 Ansung-Ansan 队列数据库 I（2001-2002 年）-III（2005-2006 年）的 7986 名 40-69 岁的受试者。我们分析了血清胆红素水平与 1 秒用力呼气量（FEV）、用力肺活量（FVC）、FEV/FVC 以及 25%至 75%用力肺活量之间平均呼气流量（FEF）在基线时的关系，以及这些肺功能参数的年度平均变化。
在调整年龄、性别、体重指数（BMI）和吸烟状况后，FEV、FVC 和 FEF 与血清胆红素水平显著相关（均 P<0.001）。按照吸烟状况分层后，在从不吸烟者中这些关系具有显著性。此外，在调整年龄、性别、BMI、基线肺功能和吸烟状况后，血清胆红素水平与 FEV 和 FVC 的年度下降呈负相关，与 FEV/FVC 的年度下降呈正相关（均 P<0.001）。
我们发现血清胆红素水平与一般人群的 FEV、FVC 和 FEF 显著相关，尤其是在从不吸烟者中。此外，血清胆红素水平与 FEV、FVC 和 FEV/FVC 比值的年度下降相关。
