韩国普通人群中抑郁症与肺功能的关系：一项回顾性横断面研究。
Relationship between depression and lung function in the general population in Korea: a retrospective cross-sectional study.
作者信息
Park Youngmok, Jung Ji Ye, Kim Young Sam, Chung Kyung Soo, Song Joo Han, Kim Song Yee, Kim Eun Young, Kang Young Ae, Park Moo Suk, Chang Joon, Leem Ah Young
机构信息
Division of Pulmonology, Department of Internal Medicine, Institute of Chest Disease, Severance Hospital, Yonsei University College of Medicine, Seodaemun-gu, Seoul, South Korea,
出版信息
Int J Chron Obstruct Pulmon Dis. 2018 Jul 18;13:2207-2213. doi: 10.2147/COPD.S169025. eCollection 2018.
BACKGROUND
Lung function and depression are closely related to many chronic lung diseases. However, few studies have evaluated this association in the general population. In this study, we evaluated the relationship between lung function and depression in the general population in Korea.
PARTICIPANTS AND METHODS
Data from the Ansung-Ansan cohort, a community-based cohort in Korea, were used to analyze the relationships between depression and lung function parameters. A total of 3,321 men and women aged 40-69 years were enrolled. Spirometry data included the forced expiratory volume in 1 second (FEV), forced vital capacity (FVC), and the FEV/FVC ratio. Depression was defined as a score of ≥16 by the Beck Depression Inventory (BDI). A propensity score analysis was conducted with the aim of reducing the bias of the retrospective study.
RESULTS
The overall prevalence of depression in the study population was 13.1% (434/3,321 participants). Depression was significantly more prevalent in women than in men (<0.001) and in never smokers than in ever smokers (<0.001). The group with depression was older (<0.001) and had a lower average body mass index (BMI) (=0.015) than the group without depression. The FEV (<0.001), FVC (<0.001), and FEV/FVC ratio (=0.022) were significantly lower in the group with depression than in the group without depression. After adjusting for age, sex, BMI, and smoking status, the mean FEV was lower in the group with a high BDI score than in the group with a low BDI score (=0.044). Using multiple linear regression analysis and adjusting for covariates, no statistically significant relationship between lung function and the BDI score was found. However, the BDI score and FEV were inversely related in subjects older than 50 years (=0.023).
CONCLUSION
Depression is associated with decreased lung function in the general population, especially in adults older than 50 years.
背景
肺功能与抑郁症和许多慢性肺部疾病密切相关。然而，很少有研究在普通人群中评估这种关联。在本研究中，我们评估了韩国普通人群中肺功能与抑郁症之间的关系。
参与者与方法
来自韩国安城-安山队列（一个基于社区的队列）的数据用于分析抑郁症与肺功能参数之间的关系。共纳入3321名年龄在40 - 69岁之间的男性和女性。肺功能测定数据包括一秒用力呼气容积（FEV）、用力肺活量（FVC）以及FEV/FVC比值。抑郁症定义为贝克抑郁量表（BDI）得分≥16分。进行倾向评分分析以减少回顾性研究的偏差。
结果
研究人群中抑郁症的总体患病率为13.1%（434/3321名参与者）。抑郁症在女性中的患病率显著高于男性（<0.001），在从不吸烟者中的患病率高于曾经吸烟者（<0.001）。抑郁症组比无抑郁症组年龄更大（<0.001）且平均体重指数（BMI）更低（=0.015）。抑郁症组的FEV（<0.001）、FVC（<0.001）和FEV/FVC比值（=0.022）显著低于无抑郁症组。在调整年龄、性别、BMI和吸烟状况后，BDI得分高的组的平均FEV低于BDI得分低的组（=0.044）。使用多元线性回归分析并调整协变量后，未发现肺功能与BDI得分之间存在统计学上的显著关系。然而，在50岁以上的受试者中，BDI得分与FEV呈负相关（=0.023）。
结论
抑郁症与普通人群的肺功能下降有关，尤其是在50岁以上的成年人中。
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