Emde C, Cilluffo T, Bauerfeind P, Fimmel C J, Blum A L
Stadtspital Triemli, Zurich, Switzerland.
Aliment Pharmacol Ther. 1988 Apr;2(2):135-41. doi: 10.1111/j.1365-2036.1988.tb00680.x.
We investigated the effect of a slow-release formula of trimoprostil, a prostaglandin E2 analogue, at a dose of 3 mg b.d. on circadian intragastric acidity in nine healthy volunteers using ambulatory pH-metry in a placebo-controlled study. The effect of trimoprostil was long lasting (8 hours during the night). However, it lowered gastric pH on average only by 0.4 pH units. In four of the six women severe side-effects occurred in the form of abdominal cramping, metrorrhagia, and/or diarrhoea. These disadvantages may limit the clinical use of this drug.
我们在一项安慰剂对照研究中，对9名健康志愿者使用动态pH测量法，研究了前列腺素E2类似物曲莫前列素3毫克每日两次的缓释配方对昼夜胃内酸度的影响。曲莫前列素的作用持续时间长（夜间持续8小时）。然而，它平均仅使胃内pH值降低0.4个pH单位。6名女性中有4名出现了严重的副作用，表现为腹部绞痛、子宫出血和/或腹泻。这些缺点可能会限制这种药物的临床应用。
