Emde C, Cilluffo T, Bauerfeind P, Blum A L
Division of Gastroenterology, Klinikum Steglitz der FU Berlin, West Germany.
Dig Dis Sci. 1989 Jan;34(1):79-82. doi: 10.1007/BF01536158.
In order to evaluate whether combined esophageal and gastric pH-metry is feasible without interference due to the transcardial cable, four 24-hr ambulatory esophageal pH-metries were carried out in seven healthy volunteers in a randomized order. In two studies only one glass electrode was used. It was placed 5 cm above the lower esophageal sphincter. In the two other studies an additional electrode was placed in the corpus region 10 cm below the lower esophageal sphincter. In order to obtain a wide range of pH values, misoprostol (400 micrograms) was given at 9 AM and 9:15 PM in two studies. In the two other studies placebo was given. Misoprostol exerted only a weak and short-lasting effect on gastric acidity. The four measuring conditions did not differ with respect to medians of esophageal reflux time and duration of single reflux episodes, Kendall's coefficient of concordance yielded a high reproducibility for both variables (P less than 0.0025). Thus, combined esophageal and gastric pH-metry is feasible and highly reproducible.
为了评估联合食管和胃pH测量法在无经贲门电缆干扰的情况下是否可行，对7名健康志愿者随机进行了4次24小时动态食管pH测量。在两项研究中仅使用了一个玻璃电极，将其置于食管下括约肌上方5厘米处。在另外两项研究中，在食管下括约肌下方10厘米的胃体区域额外放置了一个电极。为了获得广泛的pH值范围，在两项研究中于上午9点和晚上9:15给予米索前列醇（400微克）。在另外两项研究中给予安慰剂。米索前列醇对胃酸仅产生微弱且持续时间短的影响。四种测量条件在食管反流时间中位数和单次反流发作持续时间方面无差异，肯德尔和谐系数显示这两个变量具有高度可重复性（P小于0.0025）。因此，联合食管和胃pH测量法是可行的且具有高度可重复性。
