Dodson Crystal, Van Riper Marcia
School of Nursing, University of North Carolina Chapel Hill, Carrington Hall, CB 7460, Chapel Hill, NC 27599-27240, USA.
Per Med. 2011 Sep;8(5):533-540. doi: 10.2217/pme.11.43.
The use of genetic information to guide a patient's drug therapy will have a great influence on clinical practice within healthcare. However, despite the prospective benefits of pharmacogenetic testing, little is known regarding what clinicians actually think about this promising technology. The purpose of this study was to assess attitudes towards pharmacogenetic testing not previously highlighted within a larger study on clinicians' knowledge and attitudes about pharmacogenetic testing conducted by an interdisciplinary group of researchers at the University of North Carolina at Chapel Hill.
MATERIALS & METHODS: The sample included 184 responses to an open-ended question. A thematic analysis of these responses was completed.
The thematic analysis identified several themes that were not previously delineated within the original study. The analysis uncovered five additional themes including: application concerns, lack of successful integration, accessibility, potential harm and optimism.
Future research on the assessment of attitudes of clinicians concerning pharmacogenomics should incorporate these themes. In addition, educational activities conveying knowledge concerning pharmacogenomics needs to become readily available to healthcare providers. Finally, a study that addresses any disparity related to pharmacogenomics needs to be undertaken.
利用基因信息指导患者的药物治疗将对医疗保健领域的临床实践产生重大影响。然而，尽管药物遗传学检测具有潜在益处，但对于临床医生对这一前景广阔的技术的实际看法却知之甚少。本研究的目的是评估对药物遗传学检测的态度，这在北卡罗来纳大学教堂山分校的一个跨学科研究团队进行的关于临床医生对药物遗传学检测的知识和态度的大型研究中未曾得到突出强调。
样本包括对一个开放式问题的184份回复。对这些回复进行了主题分析。
主题分析确定了几个在原研究中未被描述的主题。分析发现了另外五个主题，包括：应用问题、缺乏成功整合、可及性、潜在危害和乐观态度。
未来关于评估临床医生对药物基因组学态度的研究应纳入这些主题。此外，需要为医疗保健提供者提供随时可得的传达药物基因组学知识的教育活动。最后，需要开展一项解决与药物基因组学相关的任何差异的研究。
