Chorti Angeliki, Bangeas Petros, Papavramidis Theodossis S, Tsoulfas Georgios
1st Propaedeutic Department of Surgery, AHEPA University Hospital of Thessaloniki, Aristotle University of Thessaloniki, Thessaloniki, Greece.
1st Department of Surgery, Papageorgiou Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Microrna. 2018;7(3):167-177. doi: 10.2174/2211536607666180525073302.
Colorectal cancer is one of the most common malignancies in both genders and liver metastasis appear in more than 50% of patients with colorectal cancer, worsening its morbidity and mortality rates. The existing methods for the diagnosis and prognosis of colorectal cancer seem to be insufficient to predict its aggressiveness, leading to poor outcomes for the patient.
MicroRNAs are small non-coding RNAs, which interact with mRNAs in a posttranscriptional stage, and have been found to be involved in pathogenesis of cancer and its metastases. Their utility in diagnosis of colorectal liver metastasis gains ground through serum or tissue examination.
Several miRNAs are related to colorectal cancer and its liver metastasis.
Some of them have oncogenic and other tumor suppressive role in the development of colorectal liver metastasis, while many of them have been proved to be correlated with the overall survival and prognosis of patients with colorectal cancer. The aim of the present review is to give a detailed account of the different miRNAs that have been described as playing a role in hepatic metastases from colorectal cancer, emphasizing their diagnostic, prognostic and therapeutic implications.
结直肠癌是男女中最常见的恶性肿瘤之一，超过50%的结直肠癌患者会出现肝转移，这使其发病率和死亡率恶化。现有的结直肠癌诊断和预后方法似乎不足以预测其侵袭性，导致患者预后不佳。
微小RNA是小的非编码RNA，在转录后阶段与信使RNA相互作用，已发现其参与癌症及其转移的发病机制。通过血清或组织检查，它们在结直肠癌肝转移诊断中的应用越来越广泛。
几种微小RNA与结直肠癌及其肝转移有关。
其中一些在结直肠癌肝转移的发生发展中具有致癌作用和其他肿瘤抑制作用，而许多已被证明与结直肠癌患者的总生存期和预后相关。本综述的目的是详细阐述已被描述为在结直肠癌肝转移中起作用的不同微小RNA，强调它们的诊断、预后和治疗意义。
