11th Department of Medical Oncology, "Iuliu Hatieganu" University of Medicine and Pharmacy , Cluj-Napoca , Romania.
Medical Oncology Department, Institute of Oncology "Prof. Ion Chiricuta" , Cluj-Napoca , Romania.
Expert Rev Proteomics. 2019 Oct;16(10):851-856. doi: 10.1080/14789450.2019.1659732. Epub 2019 Aug 29.
: The liver is the main location for metastasization in stage IV colorectal cancers. : This review intends to comprehensively present the most important studies conducted in the past few years concerning the role of miRNAs in colorectal cancer liver metastases, trying to clarify some aspects regarding tumor biology and favorite liver metastasization site. : Recent advances in tissue and serum RNA extraction has considerably improved the field of microRNAs studies. These molecules known to play a crucial role in the metastatic stage indicate a starting point in the development of clinical biomarkers with a possible role in the stratification of high-risk patients for adequate treatment.
肝脏是 IV 期结直肠癌转移的主要部位。本综述旨在全面介绍过去几年中关于 miRNAs 在结直肠癌肝转移中作用的最重要研究，试图阐明肿瘤生物学和首选肝转移部位的一些方面。组织和血清 RNA 提取的最新进展极大地促进了 microRNAs 研究领域的发展。这些已知在转移阶段发挥关键作用的分子为开发具有适当治疗高危患者分层作用的临床生物标志物提供了一个起点。
