预测恶性卵巢上皮性肿瘤患者伴有 CA-125 标志物转移的方程。
Predictive equation of metastasis in patients with malignant ovarian epithelial tumors with the Ca-125 marker.
机构信息
Rural Doctor Ministry of Public Health of Ecuador, Zone 6, Cuenca, Ecuador.
Department of Pathology of the Institute for the Fight against Cancer Society -SOLCA-Cuenca, Cuenca, Ecuador.
出版信息
BMC Cancer. 2018 May 24;18(1):587. doi: 10.1186/s12885-018-4499-y.
BACKGROUND
Cancer antigen (CA) 125 (CA-125) is used in ovarian cancer detection and monitoring, whose serum level has a positive correlation with tumor stage. The aim of this study was to obtain a prediction metastasis equation in a group of patients with ovarian cancer based on Ca-125.
METHODS
A 2-group comparative observational study was conducted at a single oncologic institution (SOLCA) in Cuenca-Ecuador. All patients who were diagnosed with ovarian cancer between January 1996 and December 2016 were included in the current study. Group 1 (G1) patients with the I and II International Federation of Gynecology and Obstetrics (FIGO) stage and Metastasis Group (MG), with III and IV stage, were subdivided. A logistic regression equation was performed to predict metastasis based on Logarithm of serum Ca-125 levels.
RESULTS
We included 85 cases in G1 and 64 patients in MG, with 47.8 ± 15 years (G1) and 57.5 ± 13.6 years (MG) of age (P < 0.001). Mortality in G1 was 2 cases (3.1%) and 53 cases (62.4%) in MG (P < 0.001). The CA-125 serum level was 163.5 ± 236 in G1 and 1220.9 ± 1940 u / ml in MG (P < 0.001). The equation to predict metastasis = (Age*0.053) + [(Logarithm Ca-125 value) * 1.078] - 8.163 with an OR 2.940 (CI 95% 2.046-4.223) P < 0.001. The sensitivity of the equation was 82.4% and the specificity was 79.7%.
CONCLUSIONS
It is possible to predict the presence of metastasis in a group of patients with ovarian cancer based on Ca-125.
背景
癌抗原（CA）125（CA-125）用于卵巢癌的检测和监测，其血清水平与肿瘤分期呈正相关。本研究的目的是基于 CA-125 为一组卵巢癌患者获得预测转移方程。
方法
在厄瓜多尔昆卡的一家单一肿瘤机构（SOLCA）进行了 2 组比较观察性研究。本研究纳入了 1996 年 1 月至 2016 年 12 月期间被诊断为卵巢癌的所有患者。根据国际妇产科联合会（FIGO）分期，将第 1 组（G1）患者分为 I 期和 II 期和转移组（MG），III 期和 IV 期。基于血清 CA-125 水平的对数，进行逻辑回归方程以预测转移。
结果
G1 组纳入 85 例，MG 组纳入 64 例，年龄分别为 47.8±15 岁（G1）和 57.5±13.6 岁（MG）（P<0.001）。G1 组死亡率为 2 例（3.1%），MG 组死亡率为 53 例（62.4%）（P<0.001）。G1 组血清 CA-125 水平为 163.5±236u/ml，MG 组为 1220.9±1940u/ml（P<0.001）。预测转移的方程为 =（年龄*0.053）+[（CA-125 值的对数）*1.078]-8.163，OR 为 2.940（95%CI 95%，2.046-4.223）P<0.001。该方程的敏感性为 82.4%，特异性为 79.7%。
结论
根据 CA-125，有可能预测一组卵巢癌患者是否存在转移。
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