Laboratory of Clinical Nutrition and Management, School of Food and Nutritional Sciences, The University of Shizuoka.
Asai Clinic.
J Atheroscler Thromb. 2019 Jan 1;26(1):39-49. doi: 10.5551/jat.42440. Epub 2018 May 22.
This study aimed to evaluate the effect of diet on serum lipids and to assess the effectiveness of long-term dietary therapy for hypertriglyceridemia.
Seventy-nine patients (34 males and 45 females) with hypertriglyceridemia were enrolled and underwent dietary counseling for 12 months based on the following three recommendations: (1) reduce carbohydrate intake, (2) increase n-3 polyunsaturated fatty acid (PUFA) intake, and (3) limit alcohol drinking. We examined the effect of dietary therapy for 6 months on serum triglyceride (TG) levels and also compared the effectiveness of dietary and combined drug therapies on preventing arteriosclerotic disease from 7 to 12 months.
We observed that serum TG levels of the patients receiving dietary counseling were decreased compared with baseline at 6 months. Body weight and serum TG levels were decreased, and serum high-density lipoprotein levels were increased in the dietary therapy alone group, whereas BW, body mass index, and abdominal circumference were decreased in the combined drug treatment group compared with baselines at 6 and 12 months. Furthermore, the dietary therapy alone group demonstrated reductions in intake of total energy, carbohydrate, and saturated fatty acids, as well as n-6/n-3 PUFA ratio compared with baselines, but only n-6/n-3 PUFA ratio was decreased in the combined drug treatment group.
This study demonstrated a decrease in serum TG level after 12 months of dietary therapy similar to drug therapy, which suggests that it is an effective treatment for hypertriglyceridemia, and heightened awareness should be made to encourage its use.The clinical trial registration number: UMIN000028860.
本研究旨在评估饮食对血清脂质的影响，并评估长期饮食疗法治疗高甘油三酯血症的效果。
共纳入 79 例高甘油三酯血症患者（男 34 例，女 45 例），根据以下 3 条建议进行了 12 个月的饮食咨询：（1）减少碳水化合物摄入，（2）增加 n-3 多不饱和脂肪酸（PUFA）摄入，（3）限制饮酒。我们检查了饮食疗法对 6 个月时血清甘油三酯（TG）水平的影响，并比较了饮食和联合药物治疗对预防动脉粥样硬化疾病的效果，时间为 7 至 12 个月。
我们观察到接受饮食咨询的患者的血清 TG 水平在 6 个月时与基线相比有所下降。仅饮食治疗组的体重和血清 TG 水平下降，血清高密度脂蛋白水平升高，而联合药物治疗组的 BW、体重指数和腰围在 6 和 12 个月时与基线相比均下降。此外，与基线相比，仅饮食治疗组的总能量、碳水化合物和饱和脂肪酸的摄入量以及 n-6/n-3 PUFA 比值降低，但联合药物治疗组仅 n-6/n-3 PUFA 比值降低。
本研究表明，12 个月的饮食疗法可降低血清 TG 水平，与药物疗法相似，提示其是治疗高甘油三酯血症的有效方法，应提高对此的认识并鼓励使用。临床试验注册号：UMIN000028860。
