肺移植受者真菌感染的早期诊断：定植与侵袭性疾病？
Early diagnosis of fungal infections in lung transplant recipients, colonization versus invasive disease?
作者信息
Herrera Sabina, Husain Shahid
机构信息
Multi-Organ Transplant Program, Division of Infectious Diseases, Transplant Infectious Diseases, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Canada.
出版信息
Curr Opin Organ Transplant. 2018 Aug;23(4):381-387. doi: 10.1097/MOT.0000000000000543.
PURPOSE OF REVIEW
The diagnosis of invasive aspergillosis remains challenging in solid organ transplants in general, and in lung transplant recipients, in particular, because of colonization. Lung transplant recipients may be over treated with antifungal drugs because of the lack of appropriate diagnostic tools.
RECENT FINDINGS
A review of the new developments of diagnostic tools and whether this help distinguishing colonization from invasive disease is presented.
SUMMARY
Efforts are being made to develop new tools that will allow us to identify which patients will develop IPA, and those who will be able to control the disease.
综述目的
侵袭性曲霉病的诊断在实体器官移植中总体上仍具有挑战性，尤其是在肺移植受者中，因为存在定植情况。由于缺乏合适的诊断工具，肺移植受者可能会接受过度的抗真菌药物治疗。
最新发现
本文综述了诊断工具的新进展以及这些进展是否有助于区分定植与侵袭性疾病。
总结
正在努力开发新工具，以便我们能够识别哪些患者会发展为侵袭性肺曲霉病（IPA），以及哪些患者能够控制该病。
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