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A Flawed Design Produces Flawed Results.有缺陷的设计会产生有缺陷的结果。
J Addict Med. 2018 May/Jun;12(3):252. doi: 10.1097/ADM.0000000000000394.
2
Reply to Dr Peltz.
J Addict Med. 2018 May/Jun;12(3):252-253. doi: 10.1097/ADM.0000000000000393.
3
Ondansetron Does Not Reduce Withdrawal in Patients With Physical Dependence on Chronic Opioid Therapy.昂丹司琼不能减少慢性阿片类药物治疗躯体依赖患者的停药反应。
J Addict Med. 2017 Sep/Oct;11(5):342-349. doi: 10.1097/ADM.0000000000000321.
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A double-blind, randomised, parallel group, multinational, multicentre study comparing a single dose of ondansetron 24 mg p.o. with placebo and metoclopramide 10 mg t.d.s. p.o. in the treatment of opioid-induced nausea and emesis in cancer patients.一项双盲、随机、平行组、跨国、多中心研究，比较口服单剂量24毫克昂丹司琼与安慰剂及口服每日三次每次10毫克甲氧氯普胺在治疗癌症患者阿片类药物引起的恶心和呕吐中的效果。
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Optimizing a therapy for opiate use disorders: Characterizing ondansetron pharmacokinetics in blood and brain.优化阿片类药物使用障碍的治疗方法：在血液和大脑中表征昂丹司琼的药代动力学。
Clin Transl Sci. 2023 Feb;16(2):216-223. doi: 10.1111/cts.13440. Epub 2022 Nov 9.

本文引用的文献

1
Ondansetron Does Not Reduce Withdrawal in Patients With Physical Dependence on Chronic Opioid Therapy.昂丹司琼不能减少慢性阿片类药物治疗躯体依赖患者的停药反应。
J Addict Med. 2017 Sep/Oct;11(5):342-349. doi: 10.1097/ADM.0000000000000321.
2
Palonosetron and hydroxyzine pre-treatment reduces the objective signs of experimentally-induced acute opioid withdrawal in humans: a double-blinded, randomized, placebo-controlled crossover study.帕洛诺司琼和羟嗪预处理可减轻人体实验性诱导急性阿片戒断的客观体征：一项双盲、随机、安慰剂对照交叉研究。
Am J Drug Alcohol Abuse. 2017 Jan;43(1):78-86. doi: 10.1080/00952990.2016.1210614. Epub 2016 Aug 11.
3
From mouse to man: the 5-HT3 receptor modulates physical dependence on opioid narcotics.从小鼠到人类：5-羟色胺3型受体调节对阿片类麻醉剂的身体依赖性。
Pharmacogenet Genomics. 2009 Mar;19(3):193-205. doi: 10.1097/FPC.0b013e328322e73d.
4
Methylnaltrexone for opioid-induced constipation in advanced illness.甲基纳曲酮用于治疗晚期疾病中的阿片类药物所致便秘。
N Engl J Med. 2008 May 29;358(22):2332-43. doi: 10.1056/NEJMoa0707377.
5
Subcutaneous methylnaltrexone for the treatment of opioid-induced constipation in patients with advanced illness: a double-blind, randomized, parallel group, dose-ranging study.皮下注射甲基纳曲酮治疗晚期疾病患者阿片类药物引起的便秘：一项双盲、随机、平行组、剂量范围研究。
J Pain Symptom Manage. 2008 May;35(5):458-68. doi: 10.1016/j.jpainsymman.2007.12.005.
6
Site(s) and mechanisms of the anti-emetic action of 5-HT3 receptor antagonists: a discussion of Professor Naylor's paper.5-羟色胺3受体拮抗剂的止吐作用位点及机制：对内勒教授论文的讨论
Br J Cancer Suppl. 1992 Dec;19:S12-3.
7
Mechanism of the anti-emetic activity of 5-HT3 receptor antagonists.5-羟色胺3受体拮抗剂的止吐活性机制。
Oncology. 1992;49(4):263-8. doi: 10.1159/000227054.
8
Concentration of ondansetron in cerebrospinal fluid following oral dosing in volunteers.
Psychopharmacology (Berl). 1992;109(4):497-8. doi: 10.1007/BF02247730.

A Flawed Design Produces Flawed Results.

作者信息

Peltz Gary

机构信息

Stanford University School of Medicine Stanford, CA.

出版信息

J Addict Med. 2018 May/Jun;12(3):252. doi: 10.1097/ADM.0000000000000394.

DOI:10.1097/ADM.0000000000000394
PMID:29794618
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5978761/
Abstract
摘要