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The oncogenic fusion protein CBFB-SMMHC downregulates CD48 to evade NK cell recognition.

作者信息

Kahlon Shira, Shreibman Dorin, Unger Tamar, Ben-Yehuda Dina, Elias Shlomo

机构信息

The Lautenberg Center for General and Tumor Immunology, Department of Immunology and Cancer Research, Institute for Medical Research Israel Canada (IMRIC), Hebrew University-Hadassah Medical School, Jerusalem, Israel.

Department of Hematology, Hadassah - Hebrew University Medical Center, Jerusalem, Israel.

出版信息

Blood Cancer J. 2018 May 24;8(5):48. doi: 10.1038/s41408-018-0082-7.

DOI:10.1038/s41408-018-0082-7
PMID:29795444
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5968028/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/534a/5968028/a3ff6b3d6554/41408_2018_82_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/534a/5968028/c0560da98b68/41408_2018_82_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/534a/5968028/a3ff6b3d6554/41408_2018_82_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/534a/5968028/c0560da98b68/41408_2018_82_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/534a/5968028/a3ff6b3d6554/41408_2018_82_Fig2_HTML.jpg

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Cell Stem Cell. 2015 Nov 5;17(5):597-610. doi: 10.1016/j.stem.2015.08.004. Epub 2015 Sep 18.
2
Immune evasion by oncogenic proteins of acute myeloid leukemia.急性髓系白血病致癌蛋白的免疫逃逸。
Blood. 2014 Mar 6;123(10):1535-43. doi: 10.1182/blood-2013-09-526590. Epub 2014 Jan 21.
3
Acute myeloid leukemia, version 2.2013.急性髓细胞白血病，2013 年版 2.0
J Natl Compr Canc Netw. 2013 Sep 1;11(9):1047-55. doi: 10.6004/jnccn.2013.0127.
4
CBFB-MYH11/RUNX1 together with a compendium of hematopoietic regulators, chromatin modifiers and basal transcription factors occupies self-renewal genes in inv(16) acute myeloid leukemia.CBFB-MYH11/RUNX1 与一系列造血调节因子、染色质修饰因子和基础转录因子一起，占据了 inv(16) 急性髓系白血病中的自我更新基因。
Leukemia. 2014 Apr;28(4):770-8. doi: 10.1038/leu.2013.257. Epub 2013 Sep 4.
5
Prospective evaluation of gene mutations and minimal residual disease in patients with core binding factor acute myeloid leukemia.核心结合因子急性髓系白血病患者基因突变和微小残留病的前瞻性评估。
Blood. 2013 Mar 21;121(12):2213-23. doi: 10.1182/blood-2012-10-462879. Epub 2013 Jan 15.
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ERG and FLI1 binding sites demarcate targets for aberrant epigenetic regulation by AML1-ETO in acute myeloid leukemia.ERG 和 FLI1 结合位点标志着 AML1-ETO 在急性髓系白血病中异常表观遗传调控的靶标。
Blood. 2012 Nov 8;120(19):4038-48. doi: 10.1182/blood-2012-05-429050. Epub 2012 Sep 14.
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HLA-C-dependent prevention of leukemia relapse by donor activating KIR2DS1.HLA-C 依赖性供体激活 KIR2DS1 预防白血病复发。
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