Centre d'Investigation Clinique Antilles Guyane, INSERM 1424, Centre Hospitalier de Cayenne, Cayenne, French Guiana.
COREVIH Guyane (Coordination de la lutte contre le VIH), Centre Hospitalier de Cayenne, Cayenne, French Guiana.
PLoS One. 2018 May 24;13(5):e0197990. doi: 10.1371/journal.pone.0197990. eCollection 2018.
In order to compute the continuum of care for French Guiana, it is necessary to estimate the total number of persons living with HIV. The main objective was to determine how many persons were infected with HIV and how many were unaware of it.
We used 2 different models to calculate the total number of persons infected with HIV: Spectrum's AIM module using CSAVR to compute incidence from case registration and vital statistics; and the ECDC model from the French Guiana HIV cohort data.
The present results show that both models led to similar results regarding the incident number of cases (i.e. for 2016 174 versus 161) and the total HIV population (in 2016 3206 versus 3539) respectively. The ECDC modeling tool showed that the proportion of undiagnosed HIV infections declined from 50% in 1990 to 15% in 2015. This amounted to a stable or slightly increasing total number of undiagnosed patients of 520.
The estimations of the total HIV population by both models show that the HIV population is still growing. The incidence rate declined in 2000 and the decline of the number of newly acquired HIV infections, after a decline after 2003 is offset by population growth. The proportion of undiagnosed infections has declined to 15% but the number of undiagnosed infections remains stable. The HIV cascade shows that despite good results for treatment in care, reaching the 909090 UNAIDS target may be difficult because a significant proportion of patients are lost to follow-up.
为了计算法属圭亚那的连续护理范围,有必要估计艾滋病毒感染者的总数。主要目标是确定有多少人感染了艾滋病毒,有多少人不知道自己感染了艾滋病毒。
我们使用了两种不同的模型来计算感染艾滋病毒的总人数:Spectrum 的 AIM 模块使用 CSAVR 来计算从病例登记和人口统计数据中得出的发病率;以及 ECDC 模型使用法属圭亚那艾滋病毒队列数据。
目前的结果表明,这两种模型在发病例数(即 2016 年 174 例与 161 例)和总艾滋病毒人群(2016 年 3206 例与 3539 例)方面得出了相似的结果。ECDC 建模工具显示,未确诊的艾滋病毒感染比例从 1990 年的 50%下降到 2015 年的 15%。这相当于未确诊患者的总数稳定或略有增加,为 520 人。
两种模型对总艾滋病毒人群的估计都表明,艾滋病毒人群仍在增长。发病率在 2000 年下降,新感染艾滋病毒人数的下降,在 2003 年后下降后,被人口增长所抵消。未确诊感染的比例已降至 15%,但未确诊感染的人数仍保持稳定。艾滋病毒传播链表明,尽管在治疗方面取得了良好的效果,但要实现联合国艾滋病规划署 909090 目标可能很困难,因为很大一部分患者失去了随访。