缰核刺激频率对岛叶皮质刺激诱发的阻塞性睡眠呼吸暂停的影响。
Effects of Habenular Stimulation Frequencies on Obstructive Sleep Apnea Induced by Stimulation of Insular Cortex.
作者信息
Kang Jing, Li Ming-Xian
机构信息
The First Affiliated Hospital of Jilin University, Changchun 130021, China.
Jilin Medical University, Jilin 132013, China.
出版信息
Can Respir J. 2018 Mar 26;2018:9060678. doi: 10.1155/2018/9060678. eCollection 2018.
OBJECTIVE
To investigate the effects of high-frequency stimulation of the habenula (Hb) on obstructive sleep apnea (OSA) induced by stimulation of the insular cortex . After OSA was induced by stimulating the insular cortex (Ic) with concentric stimulating electrodes at 100 Hz in rats, the Hb was stimulated at different frequencies (50 Hz, 120 Hz, 130 Hz, and 280 Hz). The changes of apnea events and electromyography (EMG) of the genioglossus were compared before and after stimulation of the Hb.
RESULTS
With stimulation of the Ic at 100 Hz, apnea events were successfully induced with disappearance of EMG of the genioglossus. After stimulation of the Hb at 130 Hz, apnea events disappeared with significantly increased genioglossal EMG. However, such a change failed to be found at the stimulation frequencies of 50 Hz, 120 Hz, and 280 Hz.
CONCLUSION
Stimulation of the Hb at the frequency of 130 Hz could effectively inhibit OSA events induced by stimulation of the Ic.
目的
研究高频刺激缰核（Hb）对岛叶皮质刺激诱发的阻塞性睡眠呼吸暂停（OSA）的影响。在大鼠中用同心刺激电极以100Hz刺激岛叶皮质（Ic）诱发OSA后，以不同频率（50Hz、120Hz、130Hz和280Hz）刺激Hb。比较刺激Hb前后呼吸暂停事件和颏舌肌肌电图（EMG）的变化。
结果
以100Hz刺激Ic时，成功诱发呼吸暂停事件，颏舌肌EMG消失。以130Hz刺激Hb后，呼吸暂停事件消失，颏舌肌EMG显著增加。然而，在50Hz、120Hz和280Hz的刺激频率下未发现这种变化。
结论
以130Hz频率刺激Hb可有效抑制Ic刺激诱发的OSA事件。
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