淋巴母细胞系中3'非翻译区的功能变体
Functional variants of 3'UTR in lymphoblastoid cell lines.
作者信息
Pu Feifei, Chen Fengxia, Zhang Zhicai, Feng Jing, Xia Ping
机构信息
Department of Orthopedics, Wuhan No.1 Hospital, Wuhan Integrated TCM & Western Medicine Hospital, Wuhan, Hubei 430022, PR China.
Department of Medical Oncology, General Hospital of The Yangtze River Shipping, Wuhan, Hubei 430022, PR China.
出版信息
Future Sci OA. 2018 Mar 15;4(5):FSO298. doi: 10.4155/fsoa-2017-0121. eCollection 2018 Jun.
AIM
Variants of 3'UTR miRNA binding sites are significantly associated with cancer; however, roles in post-transcriptional regulation have not been elucidated.
METHODS
The regulatory and coding region single nucleotide polymorphisms (SNPs) of were identified using an online database. Single nucleotide polymorphism Function Prediction was used to predict potential functional relevance of miRNA binding sites.
RESULTS
The analysis indicated rs9313439, rs4704846, rs3087616 and rs1036199 affect possible miRNA binding sites in 3'UTR. We used additional data on genotypes and limited minor allele frequency >5% in the HapMap populations. Only rs3087616 and rs4704846 were significantly associated with .
CONCLUSION
Both rs3087616 and rs4704846 could be putative variants mediating post-transcriptional regulation of the . Deeper understanding of how 3'UTR variants influence the activity by for therapy against cancer.
目的
3'非翻译区（3'UTR）微小RNA（miRNA）结合位点的变异与癌症显著相关；然而，其在转录后调控中的作用尚未阐明。
方法
使用在线数据库鉴定 的调控区和编码区单核苷酸多态性（SNP）。利用单核苷酸多态性功能预测来预测miRNA结合位点的潜在功能相关性。
结果
分析表明rs9313439、rs4704846、rs3087616和rs1036199影响3'UTR中可能的miRNA结合位点。我们使用了关于基因型的其他数据，且在国际人类基因组单体型图计划（HapMap）群体中有限的次要等位基因频率>5%。只有rs3087616和rs4704846与 显著相关。
结论
rs3087616和rs4704846都可能是介导 的转录后调控的推定变异。更深入了解3'UTR变异如何通过 影响活性，以用于癌症治疗。
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