微转移乳腺癌患者进一步腋窝淋巴结清扫的预后意义及微转移灶数量：一项基于监测、流行病学和最终结果（SEER）数据库人群的分析
Prognostic significance of further axillary dissection in breast cancer patients with micrometastases & the number of micrometastases: a SEER population-based analysis.
作者信息
Ying-Ying Liu, Tian-Jian Yu, Guang-Yu Liu
机构信息
Department of Breast Surgery, Fudan University Shanghai Cancer Center, No. 270, Dongan Road, Xuhui District, Shanghai, 200032, PR China.
Department of Oncology, Shanghai Medical College, Fudan University, No. 130, Dongan Road, Xuhui District, Shanghai, 200032, PR China.
出版信息
Future Sci OA. 2018 Apr 23;4(5):FSO303. doi: 10.4155/fsoa-2018-0008. eCollection 2018 Jun.
AIM
To investigate the benefits of axillary dissection in patients with micrometastases.
METHODS
A review of data from the Surveillance, Epidemiology, and End Results database was performed from 2004 to 2013. Kaplan-Meier curves, Cox regression models, and propensity score matching were utilized to comprehensively evaluate the cohort.
RESULTS
Multivariate analysis after propensity score matching showed that patients with one to two micrometastases did not substantially benefit from axillary lymph node dissection in breast cancer-specific survival (p = 0.725). However, a subgroup analysis indicated that axillary dissection may benefit estrogen receptor-negative patients. Moreover, patients who carried three micrometastases had a significantly lower crude hazard ratio in breast cancer-specific survival.
CONCLUSION
Axillary lymph node dissection may have advantages in high-risk micrometastatic patients. Patients with three micrometastases should be treated with caution.
目的
探讨腋窝清扫术对微转移患者的益处。
方法
对2004年至2013年监测、流行病学和最终结果数据库中的数据进行回顾。采用Kaplan-Meier曲线、Cox回归模型和倾向评分匹配对队列进行综合评估。
结果
倾向评分匹配后的多变量分析显示，有1至2个微转移灶的患者在乳腺癌特异性生存方面未从腋窝淋巴结清扫术中获得实质性益处（p = 0.725）。然而，亚组分析表明腋窝清扫术可能对雌激素受体阴性患者有益。此外，有3个微转移灶的患者在乳腺癌特异性生存方面的粗风险比显著更低。
结论
腋窝淋巴结清扫术可能对高危微转移患者具有优势。对有3个微转移灶的患者应谨慎治疗。
Zotero 插件