State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, People's Republic of China.
Org Biomol Chem. 2018 Jun 6;16(22):4195-4198. doi: 10.1039/c8ob00650d.
Two new 6-norpolycyclic polyprenylated acylphloroglucinols (PPAPs), hypermonins A (1) and B (2), featuring an undescribed decahydroindeno[1,7-bc]furan ring system, were isolated from the leaves and twigs of Hypericum monogynum. These compounds are a pair of epimers with opposite configurations at the C-5 position. Their structures, including their absolute configurations, were determined by extensive spectroscopic analysis and electronic circular dichroism (ECD) calculations. A plausible biosynthetic pathway of 1 and 2 was also proposed. Compound 1 exhibited a significant protective effect against corticosterone-induced injury in PC12 cells.
从贯叶连翘的叶和嫩枝中分离得到两个新的 6-降多环聚异戊烯基酰基间苯三酚（PPAPs），即hypermonin A（1）和 B（2），它们具有一个未被描述的十氢茚并[1,7-bc]呋喃环系统。这些化合物是一对在 C-5 位置具有相反构型的差向异构体。通过广泛的光谱分析和电子圆二色性（ECD）计算确定了它们的结构，包括绝对构型。还提出了 1 和 2 的可能生物合成途径。化合物 1 对皮质酮诱导的 PC12 细胞损伤表现出显著的保护作用。
