铑催化β-支链烯酰胺的不对称氢化反应合成β-手性胺。
Rhodium-catalyzed asymmetric hydrogenation of β-branched enamides for the synthesis of β-stereogenic amines.
机构信息
Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P. R. China.
出版信息
Chem Commun (Camb). 2018 Jun 8;54(47):6024-6027. doi: 10.1039/c8cc02798f.
PMID:29796543
Abstract
Using a rhodium complex of a bisphosphine ligand (R)-SDP, β-branched simple enamides with a (Z)-configuration were hydrogenated to β-stereogenic amines in quantitative yields and with excellent enantioselectivities (88-96% ee).
摘要
使用双膦配体（R）-SDP 的铑配合物，（Z）-构型的β-支化简单烯酰胺定量转化为β-手性胺，具有优异的对映选择性（88-96%ee）。
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