Department of Chemistry, University of Montreal, PO Box 6128, Succursale Centre-Ville Montreal, QC H3C 3J7, Canada.
Org Biomol Chem. 2018 Jun 13;16(23):4288-4294. doi: 10.1039/c8ob00897c.
We designed and synthesized miconazole analogues containing a substituted imidazolium moiety. The structural modification of the miconazole led to a compound with high potency to prevent the formation and disrupt bacterial biofilms, as a result of accumulation in the biofilm matrix, permeabilization of the bacterial membrane and generation of reactive oxygen species in the cytoplasm.
我们设计并合成了含有取代咪唑鎓部分的咪康唑类似物。咪康唑的结构修饰导致了一种具有高效能的化合物，可以防止生物膜的形成和破坏，这是由于在生物膜基质中的积累、细菌膜的通透性和细胞质中活性氧的产生。
