Tessier Jérémie, Schmitzer Andreea R
Department of Chemistry, University of Montreal PO Box 6128, Succursale Centre-Ville Montreal QC H3C 3J7 Canada
RSC Adv. 2020 Mar 4;10(16):9420-9430. doi: 10.1039/d0ra00738b. eCollection 2020 Mar 2.
Emergence of resistant bacteria encourages us to develop new antibiotics and strategies to compensate for the different mechanisms of resistance they acquire. One of the defense mechanisms of resistant bacteria is the formation of biofilms. Herein we show that benzimidazolium salts with various flexible or rigid side chains act as strong antibiotic and antibiofilm agents. We show that their antibiofilm activity is due to their capacity to destroy the biofilm matrix and the bacterial cellular membranes. These compounds are able to avoid the formation of biofilms and disperse mature biofilms showing a universal use in the treatment of biofilm-associated infections.
耐药细菌的出现促使我们开发新的抗生素和策略，以应对它们所获得的不同耐药机制。耐药细菌的防御机制之一是生物膜的形成。在此我们表明，具有各种柔性或刚性侧链的苯并咪唑盐可作为强效抗生素和抗生物膜剂。我们表明，它们的抗生物膜活性归因于其破坏生物膜基质和细菌细胞膜的能力。这些化合物能够避免生物膜的形成并分散成熟的生物膜，显示出在治疗生物膜相关感染方面的广泛用途。
