Clinical Laboratory Sciences Department, College of Applied Medical Sciences, King Saud University, Saudi Arabia.
Medical Surgical Nursing Department, College of Nursing, King Saud University, Saudi Arabia.
FEMS Microbiol Ecol. 2018 Jun 1;94(6). doi: 10.1093/femsec/fiy065.
The peaceful phenomenon of the co-evolution between the prokaryotes (microbiota) and the eukaryotes (parasites including protozoa and helminths) in the animal gut has drawn the researchers' attention. Importantly, exploring the potential of helminths for therapeutic uses was one of the reasons behind understanding the physiological and immunological crosstalk existing between them. Here we discuss the interactive immunological associations of helminths and microbial responses individually and in combination with their hosts. Considering that there is probably crosstalk between eukaryotic organisms like helminths and protozoa with their host's gut microbiota, in this review we searched the literature identifying the privileged and favourable relationship generated between them in the host. Understanding the possibilities of the role of helminths along with gut microbiota as a black box would certainly help decode the therapeutic intrusion with helminths in experimental clinical trials, and a successful trial could be used to consider possible future and safe treatments for various immune-inflammatory diseases in humans.
动物肠道中原核生物（微生物群）与真核生物（寄生虫，包括原生动物和蠕虫）之间协同进化的平静现象引起了研究人员的关注。重要的是，探索蠕虫在治疗中的潜在用途是了解它们之间存在的生理和免疫相互作用的原因之一。在这里，我们分别讨论了蠕虫和微生物对宿主的免疫相互作用和联合反应。考虑到像蠕虫和原生动物这样的真核生物与其宿主肠道微生物群之间可能存在交叉对话，在这篇综述中，我们搜索了文献，确定了它们在宿主中产生的有利关系。了解蠕虫和肠道微生物群作为一个黑箱的作用的可能性，肯定有助于在实验临床试验中用蠕虫解码治疗干预，成功的试验可以用来考虑针对人类各种免疫炎症性疾病的未来和安全治疗方法。
