特发性慢传输型便秘：采用一种新的简化方法测量全肠道传输时间，发现阿片类拮抗剂并不能缩短该时间。
Idiopathic slow-transit constipation: whole gut transit times, measured by a new simplified method, are not shortened by opioid antagonists.
作者信息
Fotherby K J, Hunter J O
机构信息
Department of Gastroenterology, Addenbrooke's Hospital, Cambridge, UK.
出版信息
Aliment Pharmacol Ther. 1987 Aug;1(4):331-8. doi: 10.1111/j.1365-2036.1987.tb00633.x.
A simplified method for measuring mean whole gut transit time has been validated which avoids stool collection and is suitable for out-patients. Radio-opaque markers are swallowed daily for 14 days and the mean whole gut transit time is derived directly from an abdominal X-ray. Using this new technique, neither nalmefene (in a double-blind study of six patients) nor naloxone (in an open study of four patients) shortened mean whole gut transit time in idiopathic slow-transit constipation.
一种测量平均全胃肠通过时间的简化方法已得到验证，该方法无需收集粪便，适用于门诊患者。连续14天每天吞服不透X线的标志物，平均全胃肠通过时间直接由腹部X线得出。应用这项新技术，在特发性慢传输型便秘患者中，纳美芬（6例患者的双盲研究）和纳洛酮（4例患者的开放研究）均未缩短平均全胃肠通过时间。
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