Cherdantseva L A, Potapova O V, Sharkova T V, Anikina A M, Kovner A V, Troitskii A V, Shkurupy V A
Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia.
Optimum Medical Laboratory, Research-and-Educational Center, Sochi, Russia.
Bull Exp Biol Med. 2018 May;165(1):48-51. doi: 10.1007/s10517-018-4096-8. Epub 2018 May 24.
Light microscopy, immunohistochemistry, and morphometric examinations established that cell death in lung granulomas of BCG-infected mice resulted mainly from activation of receptor-mediated apoptosis, which did not prevent the persistence of the causative agent in macrophages of the granulomas and promoted the formation of pronounced fibrosis in granulomas and pulmonary interstitium.
光学显微镜检查、免疫组织化学检查和形态计量学检查证实，卡介苗感染小鼠肺部肉芽肿中的细胞死亡主要源于受体介导的细胞凋亡激活，这并未阻止病原体在肉芽肿巨噬细胞中的持续存在，反而促进了肉芽肿和肺间质中明显纤维化的形成。
