卡介苗肉芽肿病早期小鼠肝脏和肺脏中的羟脯氨酸含量与纤维生成
Hydroxyproline content and fibrogenesis in mouse liver and lungs during the early stages of BCG granulomatosis.
作者信息
Shkurupiy V A, Kim L B, Nikonova I K, Potapova O V, Cherdantseva L A, Sharkova T V
机构信息
Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia.
出版信息
Bull Exp Biol Med. 2013 Jan;154(3):299-302. doi: 10.1007/s10517-013-1935-5.
In generalized BCG granulomatosis, fibrosis starts early (on day 3) and not only around the granulomas, but also in the organs. The severity of organ fibrosis is apparently determined by the concentration of granulomas, in particular their macrophages inducing proliferation of fibroblasts in organs and granulomas as well as activation of fibrogenesis. On day 30 after infection, the degree of fibrosis in the lungs was by 6 times higher than in the liver. The increase in hydroxyproline concentration in organs in early period of infection was determined by acute stress, while on day 30 it resulted from its enhanced synthesis by granuloma fibroblasts and resident fibroblasts in organs.
在播散性卡介苗肉芽肿病中，纤维化在早期（第3天）就开始，不仅在肉芽肿周围，而且在器官中也开始。器官纤维化的严重程度显然由肉芽肿的浓度决定，特别是其巨噬细胞诱导器官和肉芽肿中的成纤维细胞增殖以及纤维生成的激活。感染后第30天，肺部的纤维化程度比肝脏高6倍。感染早期器官中羟脯氨酸浓度的增加是由急性应激决定的，而在第30天则是由肉芽肿成纤维细胞和器官中的驻留成纤维细胞合成增加所致。
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