肿瘤相关性癫痫：流行病学、发病机制与治疗。
Tumor-related epilepsy: epidemiology, pathogenesis and management.
机构信息
Department of Neuroscience, University of California, San Diego, USA.
Rady Children's Hospital San Diego, San Diego, USA.
出版信息
J Neurooncol. 2018 Aug;139(1):13-21. doi: 10.1007/s11060-018-2862-0. Epub 2018 May 24.
INTRODUCTION
Seizure is a common comorbidity in patients with brain tumor. It may be the presenting symptom or develop after the tumor diagnosis. The underlying pathophysiology of brain tumor-related epilepsy remains poorly understood.
METHODS
A comprehensive literature review of Pubmed English articles from 1980-2017 was performed to summarize current knowledge and treatment options of brain tumor-related epilepsy.
RESULTS
Multiple factors have been found to contribute to tumor-related epilepsy, including tumor type, speed of tumor growth, location, and tumor burden. The underlying pathogenesis of epilepsy is not clear but perturbations in the peri-tumoral regions, both structural and cellular communications, have been implicated.
CONCLUSIONS
Surgical and medical treatments of tumor-related epilepsy remain challenging as additional factors such as the extent of surgical resection, interactions with tumor-related oncological treatments and anti-epileptic medication related side effects need to be considered.
简介
癫痫是脑肿瘤患者常见的共病。它可能是首发症状，也可能在肿瘤诊断后出现。脑肿瘤相关癫痫的潜在病理生理学仍不清楚。
方法
对 1980 年至 2017 年 Pubmed 英文文献进行全面文献复习，总结脑肿瘤相关癫痫的现有知识和治疗选择。
结果
已发现多种因素与肿瘤相关癫痫有关，包括肿瘤类型、肿瘤生长速度、位置和肿瘤负荷。癫痫的潜在发病机制尚不清楚，但涉及到肿瘤周围区域的结构和细胞通讯的改变。
结论
肿瘤相关癫痫的手术和药物治疗仍然具有挑战性，因为需要考虑其他因素，如手术切除的范围、与肿瘤相关的肿瘤治疗的相互作用以及抗癫痫药物的相关副作用。
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