Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, 361021, People's Republic of China.
University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China.
Environ Sci Pollut Res Int. 2018 Aug;25(22):22023-22034. doi: 10.1007/s11356-018-2331-5. Epub 2018 May 25.
Antibiotics are used to fight diseases in humans and farm animals. Their residues, however, can enter aquatic environments and affect the resistance of non-target microbial strains, and the prevalence of antibiotic resistance genes (ARGs) potentially poses negative impacts on human health. In order to better understand how the studies of antibiotics have been conducted, we analyzed the publications on antibiotics in aquatic systems for the period of 1945-2017. We applied a bibliometric analysis method by coupling cluster analysis and network analysis. Results indicated that early research on antibiotics in water was mostly performed in America and Europe, while, in recent years, publications for the same subject were dominated by China and the USA. The majority of the articles were published in journal Chemosphere and the most representative subject categories of the seven sections were "Environmental science and ecology," "Chemistry," "Engineering," "Biochemistry and molecular biology," "Water resources," "Agriculture," and "Pharmacology and pharmacy." The most studied class of antibiotics was tetracyclines in wastewater. Antibiotic resistance, ARGs, Escherichia coli, and some mechanistic studies such as adsorption, toxicity, degradation, and kinetics were common topics in this field. ARGs present a major public health concern and much attention should be directed at the problems with antibiotics in the future studies of water.
抗生素被用于治疗人类和农场动物的疾病。然而，它们的残留会进入水生环境，影响非靶标微生物菌株的抗性，抗生素抗性基因（ARGs）的流行可能对人类健康造成负面影响。为了更好地了解抗生素的研究情况，我们对 1945 年至 2017 年期间水生系统中抗生素的研究进行了文献计量分析。我们应用了一种结合聚类分析和网络分析的文献计量分析方法。结果表明，早期水中抗生素的研究主要集中在美洲和欧洲，而近年来，同一主题的出版物主要由中国和美国主导。这些文章大多发表在《Chemosphere》期刊上，七个部分中最具代表性的学科类别是“环境科学与生态学”、“化学”、“工程”、“生物化学与分子生物学”、“水资源”、“农业”和“药理学与药剂学”。废水中研究最多的抗生素类别是四环素。抗生素耐药性、ARGs、大肠杆菌以及一些如吸附、毒性、降解和动力学等机制研究是该领域的常见主题。ARGs 是一个主要的公共卫生关注点，未来的水研究应该更加关注抗生素问题。
