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毛干角蛋白和角蛋白相关蛋白的多样性。

Diversity of Trichocyte Keratins and Keratin Associated Proteins.

机构信息

AgResearch Ltd., Lincoln, New Zealand.

出版信息

Adv Exp Med Biol. 2018;1054:21-32. doi: 10.1007/978-981-10-8195-8_3.

DOI:10.1007/978-981-10-8195-8_3
PMID:29797265
Abstract

Wool and hair fibres are primarily composed of proteins of which the keratins and keratin associated proteins (KAPs) are the major component. Considerable diversity is known to exist within these two groups of proteins. In the case of the keratins two major families are known, of which there are 11 members in the acidic Type I family and 7 members in the neutral-basic Type II family. The KAPs are even more diverse than the keratins, with 35 families being known to exist when the KAPs found in monotremes, marsupials and other mammalian species are taken into consideration. Human hair and wool are known to have 88 and 73 KAPs respectively, though this number rises for wool when polymorphism within KAP families is included.

摘要

羊毛和头发纤维主要由蛋白质组成,其中角蛋白和角蛋白相关蛋白(KAP)是主要成分。这两种蛋白质群内存在着相当大的多样性。在角蛋白的情况下,已知有两个主要家族,其中酸性 I 型家族有 11 个成员,中性-碱性 II 型家族有 7 个成员。角蛋白相关蛋白比角蛋白更加多样化,当考虑到单孔目动物、有袋动物和其他哺乳动物物种中的角蛋白相关蛋白时,已知有 35 个家族存在。已知人类毛发和羊毛分别有 88 种和 73 种角蛋白相关蛋白,但当包括角蛋白家族内的多态性时,羊毛的数量会增加。

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