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从体重小于 10 公斤的供者移植小儿肾移植。

Transplantation of pediatric renal allografts from donors less than 10 kg.

机构信息

Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.

Department of Surgery, Western University, London, ON, Canada.

出版信息

Am J Transplant. 2018 Nov;18(11):2689-2694. doi: 10.1111/ajt.14946. Epub 2018 Jun 27.

Abstract

Few transplant programs use kidneys from donors with body weight (BW) < 10 kg. We hypothesized that pediatric en bloc transplants from donors with BW < 10 kg would provide similar transplant outcomes to larger grafts. All pediatric en bloc renal transplants performed at our center between 2001 and 2017 were reviewed (N = 28). Data were stratified by smaller (donor BW < 10 kg; n = 11) or larger donors (BW > 10 kg; n = 17). Renal volume was assessed during follow-up with ultrasound. Demographic characteristics were similar between the 2 groups of recipients. After mean follow-up of 44 months (smaller donors) and 124 months (larger donors), graft and patient outcomes were similar between groups. Serum creatinine at 1, 3, and 5 years was no different between groups. At 1 day posttransplant, mean total renal volume in the smaller donors was 28 ± 9 mm vs 45 ± 12 mm (P < .01). By 3 weeks, it was 53 ± 19 mm (smaller donors) versus 73 ± 19 mm (larger donors) (P = NS). Complication rates were similar between both groups with 1 case of venous thrombosis in the smaller group. With experience, outcomes are equivalent to those from larger pediatric donors.

摘要

很少有移植项目使用体重(BW)<10kg 的供体肾脏。我们假设,来自 BW<10kg 的供体的小儿整块移植将提供与更大移植物相似的移植结果。我们中心在 2001 年至 2017 年间进行的所有小儿整块肾移植均进行了回顾(N=28)。数据根据较小的供体(BW<10kg;n=11)或较大的供体(BW>10kg;n=17)进行分层。在随访期间通过超声评估肾脏体积。两组受者的人口统计学特征相似。在平均随访 44 个月(较小供体)和 124 个月(较大供体)后,两组的移植物和患者结局相似。两组患者的 1、3 和 5 年血清肌酐无差异。移植后 1 天,较小供体的总肾脏体积为 28±9mm,而较大供体为 45±12mm(P<.01)。3 周时,较小供体为 53±19mm,而较大供体为 73±19mm(P=NS)。两组并发症发生率相似,较小组有 1 例静脉血栓形成。随着经验的积累,结果与来自较大的儿科供体的结果相当。

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