使用丙型肝炎阳性供体器官进行移植后丙型肝炎病毒基因型的变化。

Hepatitis C genotype change after transplantation utilizing hepatitis C positive donor organs.

作者信息

Adekunle R, Jonchhe S, Ravichandran B, Wilson E, Husson J

机构信息

Department of Medicine, University of Maryland Medical Center, Baltimore, MD, USA.

University of Maryland School of Pharmacy, Baltimore, MD, USA.

出版信息

Transpl Infect Dis. 2018 Aug;20(4):e12925. doi: 10.1111/tid.12925. Epub 2018 Jun 13.

DOI:10.1111/tid.12925

PMID:29797655

Abstract

A shortage in organs for transplantation has led to the increased use of hepatitis C (HCV) infected donor organs for solid organ transplant recipients infected with HCV. However, the donor HCV genotype is not routinely checked or known prior to transplant. Here, we report 4 cases of genotype conversion after transplantation in patients receiving HCV infected donor organs. This change in genotype may potentially impact HCV progression as well as treatment choice for these patients.

摘要

器官移植供体短缺导致越来越多地将感染丙型肝炎病毒（HCV）的供体器官用于感染HCV的实体器官移植受者。然而，在移植前通常不会常规检查或知晓供体的HCV基因型。在此，我们报告了4例接受感染HCV供体器官的患者在移植后发生基因型转换的病例。这种基因型的变化可能会对这些患者的HCV病情进展以及治疗选择产生潜在影响。