Yang S H, Ma L, Li K, Lv Y H, Sun R, Xiang Y, Huang D J, Yang J L
Kunming University of Science and Technology Faculty of Information Engineering and Automation,Kunming,650500,China.
Department of Respiratory Medicine,the First People's Hospital of Yunnan Province,Kunming.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 Aug 20;30(16):1297-1301;1307. doi: 10.13201/j.issn.1001-1781.2016.16.009.
The aim of this study is to assess the association between obstructive sleep apnea-hypopnea syndrome and type 2 diabetes (T2DM).Databases such as Chinese Biomedical Literature Database,PubMed,Chinese Academic Journals full-text database,Wanfang Resource Database and Chongqing VIP have been searched to collect literatures about the relationship between OSAHS and type 2 diabetes.The papers and unpublished articles were also manually retrieved.Randomized controlled trial conformed to the condition were evaluated according to the standards of literature assessment,and the data has been extracted.The RevMan5.3 software was applied to carry out Meta-analysis.Thirty studies are includedin the Meta-analysis.The fasting glucose content of OSAHS patients with T2DM is significantly higher than T2DM patients[WMD=1.01,95%CI(0.55,1.46), <0.01];OSAHS with T2DM patients' apnea hypopnea index is significantly higher than OSAHS patients[WMD=3.78,95%CI(1.69,5.87),<0.01];the fasting glucose content of OSAHS patients is also significantly higher than normal [WMD=1.16,95CI%(0.88,1.44),<0.01];When stratified by rhe grades of OSAHS,we found fasting glucose content of all OSAHS patients is significantly higher than normal[WMD=1.09,95CI% (0.97,1.21),<0.01];the funnel flot appeared to be symmetrical with little bias.The experimental results indicate that OSAHS is significantly related with T2DM ,and they may be the risk factorof each other.
本研究旨在评估阻塞性睡眠呼吸暂停低通气综合征与2型糖尿病（T2DM）之间的关联。检索了中国生物医学文献数据库、PubMed、中国学术期刊全文数据库、万方资源数据库和重庆维普等数据库，以收集有关阻塞性睡眠呼吸暂停低通气综合征（OSAHS）与2型糖尿病关系的文献。还人工检索了论文和未发表的文章。根据文献评估标准对符合条件的随机对照试验进行评估，并提取数据。应用RevMan5.3软件进行Meta分析。Meta分析纳入了30项研究。伴T2DM的OSAHS患者的空腹血糖含量显著高于T2DM患者[加权均数差（WMD）=1.01，95%置信区间（CI）（0.55，1.46），P<0.01]；伴T2DM的OSAHS患者的呼吸暂停低通气指数显著高于OSAHS患者[WMD=3.78，95%CI（1.69，5.87），P<0.01]；OSAHS患者的空腹血糖含量也显著高于正常水平[WMD=1.16，95%CI（0.88，1.44），P<0.01]；按OSAHS分级进行分层时，我们发现所有OSAHS患者的空腹血糖含量均显著高于正常水平[WMD=1.09，95%CI（0.97，1.21），P<0.01]；漏斗图显示对称，偏倚较小。实验结果表明，OSAHS与T2DM显著相关，它们可能互为危险因素。
