Tang X, Yang L X, Zhang M, Zhou N, Yan J
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2017 Oct 5;31(19):1540-1544. doi: 10.13201/j.issn.1001-1781.2017.19.019.
To review the application of proteomics and metabolomics in the study of OSAHS biomarkers,and to open a new perspective for the study of OSAHS. At present,these studies are still in a very preliminary stage,the results are not always consistent,and far from the clinical application requirements. However,compared with traditional chemical methods,quantitative protein and metabolomics methods still have many advantages and have great clinical potential. Further studies of larger populations for more detailed grouping in the future are necessary to validate these results,and a more structured investigation in cell and animal models is necessary to determine their molecular mechanisms. In addition,the combination of different analytical platforms will be the ideal method for OSAHS biomarker research. In conclusion,the proteomics and metabolomics methods help us to better understand the potential mechanisms of OSAHS and to discover and develop personalized screening,diagnosis,prognostic and therapeutic strategies for future research.
综述蛋白质组学和代谢组学在阻塞性睡眠呼吸暂停低通气综合征（OSAHS）生物标志物研究中的应用，为OSAHS的研究开辟新视角。目前，这些研究仍处于非常初步的阶段，结果并不总是一致，且远未达到临床应用要求。然而，与传统化学方法相比，定量蛋白质组学和代谢组学方法仍具有许多优势，具有巨大的临床潜力。未来有必要对更大规模人群进行更详细的分组研究以验证这些结果，并且有必要在细胞和动物模型中进行更系统的研究以确定其分子机制。此外，不同分析平台的结合将是OSAHS生物标志物研究的理想方法。总之，蛋白质组学和代谢组学方法有助于我们更好地理解OSAHS的潜在机制，并为未来研究发现和开发个性化的筛查、诊断、预后和治疗策略。
