Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2018 Apr;32(8):634-638. doi: 10.13201/j.issn.1001-1781.2018.08.020.
Competitive endogenous RNA(ceRNA) refers to the regulatory model that RNAs can regulate each other expression by competing for common miRNA response elements at post-transcriptional levels. The ceRNA network links the function of protein-coding genes(mRNAs) with the functions of non-coding RNAs (such as miRNAs, long non-coding RNAs, pseudogenes transcripts,and circular RNAs) and plays an important role in the development of multiple tumors. The head and neck carcinoma is a highly aggressive malignant tumor. Although the treatment methods continue to improve,the survival rate of head and neck carcinoma patients has no more significant improvement. It is particularly important to explore the molecular mechanisms of the development and metastasis of head and neck carcinoma,look for specific molecular diagnostic markers and therapeutic targets.We summarize the role of ceRNA regulatory networks in the development of head and neck carcinoma in the present review.
竞争性内源RNA（ceRNA）是指RNA可通过在转录后水平竞争共同的微小RNA（miRNA）反应元件来相互调节表达的调控模式。ceRNA网络将蛋白质编码基因（mRNA）的功能与非编码RNA（如miRNA、长链非编码RNA、假基因转录本和环状RNA）的功能联系起来，在多种肿瘤的发生发展中发挥重要作用。头颈癌是一种侵袭性很强的恶性肿瘤。尽管治疗方法不断改进，但头颈癌患者的生存率并无更显著提高。探索头颈癌发生发展和转移的分子机制、寻找特异性分子诊断标志物和治疗靶点尤为重要。在本综述中，我们总结了ceRNA调控网络在头颈癌发生发展中的作用。
