Feng Q
Department of Neurology, Zhengzhou People's Hospital, Zhengzhou, 450012, China.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2017 Jul 5;31(13):1017-1021. doi: 10.13201/j.issn.1001-1781.2017.13.012.
To analyze the correlation between obstructive sleep apnea syndrome (OSAHS) and cognitive impairment and functional status after stroke. From February 2014 to September 2016, a total of 189 patients were included in the study, 33 patients with mild OSAHS were excluded, and finally 86 patients in the study group and 70 patients in the control group were included in the final analysis. The main indicators included the cognitive and functional status. Cognitive status was assessed by nine dimensions: vigilance, attention, memory, working memory, executive, language, insight, mental activity, psychomotor, and intelligence. Functional status was assessed using neurological status and functional independence. Secondary measures included sleepiness, fatigue, anxiety and depression, and sleep quality. The age of the study group was higher than the control group, the BMI was higher than the control group, the average hospitalization time was longer than the control group, and all of the difference were statistically significant (all <0.05). The total cognitive status of the two groups was significantly different, and the total cognitive status study group was significantly worse than in the control group (=9.276, =0.012). In the nine dimensions of cognitive ability, the study group's attention, execution, insight, mental adjustment and intelligence were lower than the control group, and the difference was statistically significant (<0.05). The functional status of the study group was worse than that of the control group (=38.094, =0.000). There were no significant differences between the two groups in terms of sleepiness, fatigue, sleep quality, anxiety and depression (>0.05). The cognitive impairment and functional status of stroke patients with OSAHS are significantly worse. OSAHS is a risk factor for poor prognosis in stroke patients.
分析阻塞性睡眠呼吸暂停低通气综合征（OSAHS）与卒中后认知障碍及功能状态之间的相关性。2014年2月至2016年9月，共有189例患者纳入研究，排除33例轻度OSAHS患者，最终研究组86例患者和对照组70例患者纳入最终分析。主要指标包括认知和功能状态。认知状态通过九个维度进行评估：警觉性、注意力、记忆力、工作记忆、执行力、语言能力、洞察力、精神活动、精神运动和智力。功能状态采用神经学状态和功能独立性进行评估。次要指标包括嗜睡、疲劳、焦虑和抑郁以及睡眠质量。研究组年龄高于对照组，体质指数高于对照组，平均住院时间长于对照组，所有差异均有统计学意义（均P<0.05）。两组总认知状态有显著差异，研究组总认知状态显著差于对照组（F=9.276，P=0.012）。在认知能力的九个维度中，研究组的注意力、执行力、洞察力、精神调节和智力低于对照组，差异有统计学意义（P<0.05）。研究组的功能状态比对照组差（F=38.094，P=0.000）。两组在嗜睡、疲劳、睡眠质量、焦虑和抑郁方面无显著差异（P>0.05）。合并OSAHS的卒中患者认知障碍及功能状态显著更差。OSAHS是卒中患者预后不良的危险因素。
