Kasprzak A, Nussdorfer G G, Malendowicz L K
Department of Histology and Embryology, Poznan Academy of Medicine, Poland.
In Vivo. 1988 Mar-Apr;2(2):119-22.
The relative adrenal weight of the remaining right adrenal gland was significantly increased 5 days after unilateral adrenalectomy in hamsters of both sexes. This effect was associated with an enlargement of the zonae glomerulosa and fasciculata in males and of the zona fasciculata in females. Unilateral adrenalectomy raised the average volume of zona fasciculata cells in male hamsters and that of zona reticularis cells in females. The number of parenchymal cells in all adrenocortical zones remained unchanged by the removal of the contralateral gland; however, when calculating per mg of adrenal or per cell, the nucleotide uptake by adrenal quarters was notably lowered. A marked drop in plasma cortisol concentration was found in unilaterally adrenalectomized male but not in female hamsters. These findings indicate that the main component of the adrenal compensatory growth in hamsters is the hypertrophy and not the hyperplasia of parenchymal cells.
在两性仓鼠单侧肾上腺切除术后5天，剩余右侧肾上腺的相对重量显著增加。这种效应与雄性仓鼠的球状带和束状带以及雌性仓鼠的束状带增大有关。单侧肾上腺切除术增加了雄性仓鼠束状带细胞的平均体积以及雌性仓鼠网状带细胞的平均体积。切除对侧肾上腺后，所有肾上腺皮质区的实质细胞数量保持不变；然而，当按每毫克肾上腺或每细胞计算时，肾上腺四分之一区域的核苷酸摄取量显著降低。在单侧肾上腺切除的雄性仓鼠中发现血浆皮质醇浓度显著下降，但在雌性仓鼠中未发现。这些发现表明，仓鼠肾上腺代偿性生长的主要成分是实质细胞的肥大而非增生。
