Antitumor effect of 24R,25-dihydroxyvitamin D3.
作者信息
Maeda Y, Hirai T, Yamato H, Kobori N, Matsunaga K, Oguchi Y, Yoshimura M, Fujii T, Kobayashi Y, Saitoh K
机构信息
Biomedical Research Laboratories, Kureha Chemical Industry Co., Ltd., Tokyo, Japan.
出版信息
In Vivo. 1988 Mar-Apr;2(2):129-32.
PMID:2979828
Abstract
24R,25(OH)2D3, one of the endogenous active metabolites of vitamin D3, showed suppressive effects on the proliferation of various tumor cells in vitro and a prolonging effect on the survival of P-388 bearing mice in vivo. Lewis lung carcinoma was found to cause hypercalcemia in tumor bearing mice. K-DR (24R,25(OH)2D3 (prepared by Kureha Chemical Ind.) significantly prolonged the survival of mice with Lewis lung carcinoma. K-DR also showed a suppressive effect on the growth of human osteosarcoma transplanted in nude mice.
摘要
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