24R,25-二羟胆钙化醇对Lewis肺癌荷瘤小鼠钙代谢异常的抗肿瘤及其他作用
Antitumor and other effects of 24R,25-dihydroxycholecalciferol in Lewis lung carcinoma causing abnormal calcium metabolism in tumor-bearing mice.
作者信息
Maeda Y, Yamato H, Hirai T, Kobori N, Fujii T, Kobayashi Y, Saitoh K, Inoguchi E, Hakozaki M, Iijima H
机构信息
Biomedical Research Laboratories, Kureha Chemical Industry Co., Ltd., Tokyo, Japan.
出版信息
Oncology. 1988;45(3):202-5. doi: 10.1159/000226562.
PMID:3368196
Abstract
Lewis lung carcinoma was found to cause hypercalcemia in tumor-bearing mice. 24R,25(OH)2D3 (K-DR, prepared by Kureha Chemical Ind.) significantly prolonged the survival time of mice with Lewis lung carcinoma. K-DR exhibited an antimetastatic effect on Lewis lung carcinoma, and also had an analgesic effect in mice with Lewis lung carcinoma.
摘要
发现Lewis肺癌可导致荷瘤小鼠出现高钙血症。24R,25(OH)2D3（K-DR，由吴羽化学工业株式会社制备）显著延长了Lewis肺癌小鼠的存活时间。K-DR对Lewis肺癌具有抗转移作用，并且对Lewis肺癌小鼠也有镇痛作用。
Zotero 插件