在生长缓慢的大鼠白血病模型中对棕榈酸视黄酯和阿糖胞苷治疗的评估。
Evaluation of retinyl palmitate and cytarabine treatment in a slowly growing rat leukemia model.
作者信息
Wathne K O, Lie S O, Colly L
机构信息
Institute for Nutrition Research, School of Medicine, University of Oslo, Norway.
出版信息
In Vivo. 1988 Mar-Apr;2(2):139-41.
The slowly effect of retinyl palmitate in prolonging survival time in a slowly growing rat promyelocytic leukemia model (BNML) was tested. Retinyl palmitate was given in addition to cytarabine, which has previously been shown to prolong survival time in these rats. The effect of cytarabine on liver store and plasma level of retinol was also tested. The results show that retinyl palmitate did not prolong survival time in the leukemic rats. Similarly, cytarabine did not reduce the level of retinol in liver or plasma.
在生长缓慢的大鼠早幼粒细胞白血病模型（BNML）中，测试了棕榈酸视黄酯延长存活时间的缓慢效果。除了阿糖胞苷外还给予了棕榈酸视黄酯，阿糖胞苷此前已被证明可延长这些大鼠的存活时间。还测试了阿糖胞苷对肝脏视黄醇储存和血浆视黄醇水平的影响。结果表明，棕榈酸视黄酯并未延长白血病大鼠的存活时间。同样，阿糖胞苷也未降低肝脏或血浆中的视黄醇水平。
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