Zhu Y Q, Liu Y H
Department of Otolaryngology Head and Neck Surgery, Second Affiliated Hospital of Nanchang University, Nanchang, 330006, China.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2017 Dec 20;31(24):1940-1943. doi: 10.13201/j.issn.1001-1781.2017.24.019.
Allergic rhinitis (AR) is the Th2 inflammatory response that atopic individuals exposure to allergens, mediators released by IgE-mediated, and a variety of immunocompetent cells and cytokines involved .Group 2 innate lymphoid cells (ILC2) are a novel population of native lymphocyte, can secrete large amounts of Th2 cytokines to promote the development of allergic diseases after being activated. MiR-155 plays a vital role in the development of the immune system, the differentiation of immune cells, and the maintenance of immune function.Nasal mucosas from the patients with allergic rhinitis show enrichment for ILC2 and miR-155. Highly expressed miR-155 may enhance the level of IL-4 by promoting ILC2 expression, thereby promoting Th2 inflammatory response.This review focuses on the function and meaning of ILC2 and miR-155 in patients with Allergic rhinitis.
变应性鼻炎（AR）是特应性个体接触变应原后发生的Th2炎症反应，由IgE介导释放介质，并涉及多种免疫活性细胞和细胞因子。2型固有淋巴细胞（ILC2）是一类新型的天然淋巴细胞，被激活后可分泌大量Th2细胞因子，促进变应性疾病的发展。MiR-155在免疫系统发育、免疫细胞分化及免疫功能维持中发挥着至关重要的作用。变应性鼻炎患者的鼻黏膜显示ILC2和miR-155富集。高表达的miR-155可能通过促进ILC2表达来提高IL-4水平，从而促进Th2炎症反应。本综述重点关注ILC2和miR-155在变应性鼻炎患者中的作用及意义。
