Lei Zhu, Feng Guangrui, Wang Zhiguo, Ning Zhifeng
Otolaryngology Department, Xianning First People's Hospital, Xianning 437100, Hubei, China.
Cardiovascular Medicine Department, The First Affiliated Hospital of Hubei University of Science and Technology, Xianning 437100, Hubei, China.
Evid Based Complement Alternat Med. 2022 Oct 15;2022:1979447. doi: 10.1155/2022/1979447. eCollection 2022.
Allergic rhinitis (AR) is a type I hypersensitivity reaction disease caused by inhaled allergens and immunoglobulin (IgE)-mediated. Noncoding RNA (ncRNA) is an important regulator involved in gene expression and can be detected in the cytoplasm or extracellular fluid, which mainly includes microRNAs (miRNA, length 22-24 nucleotides), long noncoding RNAs (lncRNA, length >200 nucleotides), and circRNAs. LncRNA and miRNA both participate in the regulation of immune function. Some respiratory viral infections can aggravate allergic rhinitis, such as a respiratory syncytial virus (RSV) and human metapneumovirus (hMPV). However, the interaction between viral infection and allergy is complex and the mechanism is still unclear. In this review, we summarized the interactions of noncoding RNAs and viruses in the occurrence and development of AR, along with the treatments focusing on the noncoding RNAs in the past five years.
变应性鼻炎（AR）是一种由吸入性变应原引起的、免疫球蛋白（IgE）介导的I型超敏反应性疾病。非编码RNA（ncRNA）是参与基因表达的重要调节因子，可在细胞质或细胞外液中检测到，主要包括微小RNA（miRNA，长度为22 - 24个核苷酸）、长链非编码RNA（lncRNA，长度>200个核苷酸）和环状RNA（circRNA）。LncRNA和miRNA均参与免疫功能的调节。一些呼吸道病毒感染可加重变应性鼻炎，如呼吸道合胞病毒（RSV）和人偏肺病毒（hMPV）。然而，病毒感染与过敏之间的相互作用较为复杂，其机制仍不清楚。在这篇综述中，我们总结了过去五年非编码RNA与病毒在AR发生发展中的相互作用，以及针对非编码RNA的治疗方法。
