Ji X Q, Zhang N K, Shao M J, Liu T T, Li S L
Department of Otolaryngology,the First People's Hospital of Qingdao Economic and Technological Development Zone,Qingdao,266555,China.
Department of Otolaryngology,Affiliated Hospital of Medical College of Qingdao University.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 Aug 5;30(15):1236-1239. doi: 10.13201/j.issn.1001-1781.2016.15.015.
The aim of this study was to observe the changes of pulmonary function in patients with allergic rhinitis and the effect of nasal glucocorticoid on pulmonary function.Ninety patients with Moderate and severe AR and 50 healthy control subjects were recruited.All participates accepted a pulmonary function test and make a statistical analysis.90 patients of AR were divided into two groups:A group(50) and B group(40).A group treated with nasal budesonide and loratadine,while B group treated with nasal normal saline and loratadine.After 3 months,all patients reviewed the lung function.Comparing with control,FEV1.0/FVC,MMEF,FEF50% and FEF75% reduced significantly in AR group(<0.01),after 3 months,the treatment of A group compared before:FEV1.0/FVC(<0.05),MMEF,FEF50% and FEF75%(<0.01) had statistical significance.Compared B group after the treatment:FEF75% (<0.05) was significant.After the treatment of group A compared with normal group:there was no significance.The reduced pulmonary function of allergic rhinitis paitents is mainly due to the small airway dysfunction.Budesonide is superior to loratadine to improve the pulmonary function.
本研究旨在观察变应性鼻炎患者肺功能的变化以及鼻用糖皮质激素对肺功能的影响。招募了90例中重度变应性鼻炎患者和50名健康对照者。所有参与者均接受肺功能测试并进行统计分析。90例变应性鼻炎患者分为两组：A组（50例）和B组（40例）。A组采用布地奈德鼻喷雾剂和氯雷他定治疗，而B组采用生理盐水滴鼻和氯雷他定治疗。3个月后，所有患者复查肺功能。与对照组相比，变应性鼻炎组FEV1.0/FVC、MMEF、FEF50%和FEF75%显著降低（<0.01），3个月后，A组治疗前后比较：FEV1.0/FVC（<0.05）、MMEF、FEF50%和FEF75%（<0.01）有统计学意义。B组治疗后比较：FEF75%（<0.05）有显著性差异。A组治疗后与正常组比较：无显著性差异。变应性鼻炎患者肺功能降低主要是由于小气道功能障碍。布地奈德在改善肺功能方面优于氯雷他定。
