Botilsrud M, Wathne K O, Norum K R, Blomhoff R
Institute for Nutrition Research, School of Medicine, University of Oslo, Norway.
In Vivo. 1988 May-Aug;2(3-4):253-6.
The effect of various antiepileptics on the retinol storage in rat liver was tested. We observed a dose- and time-dependent reduction in the hepatic storage of retinol after the administration of several of these drugs. Administration for 11 weeks of phenobarbital, primidone and carbamazepine in doses comparable to those used in humans reduced the retinol concentration in the Liver by 17-33% compared to control rats. The plasma retinol levels remained unaffected in all the rats. Plasma retinol from 31 epileptic children had plasma levels between 0.7 and 2.4 nmol/ml, which is regarded as normal.
测试了各种抗癫痫药物对大鼠肝脏中视黄醇储存的影响。我们观察到，在给予其中几种药物后，肝脏中视黄醇的储存量呈剂量和时间依赖性减少。以与人类使用剂量相当的剂量给予苯巴比妥、扑米酮和卡马西平11周后，与对照大鼠相比，肝脏中的视黄醇浓度降低了17% - 33%。所有大鼠的血浆视黄醇水平均未受影响。31名癫痫儿童的血浆视黄醇水平在0.7至2.4 nmol/ml之间，这被视为正常。
