Fruncillo R J, Ruch E K, DiGregorio G J
Res Commun Chem Pathol Pharmacol. 1986 Nov;54(2):283-6.
The distribution of vitamin A was measured in various body fluids and tissues in rats with carbon tetrachloride induced acute liver injury compared to vehicle treated controls. All rats received 25,000u of retinol palmitate intraperitoneally 24 hr prior to study and 50,000u on the day of the study. Rats with liver injury had significant elevations of unesterified retinol in plasma and saliva, and significant elevations of retinol palmitate in plasma, urine, and kidney. Also, liver disease caused a significant decrease in the liver concentration of retinol palmitate, and a significant decrease in the bile and kidney levels of unesterified retinol. These results suggest that redistribution of vitamin A from liver to other areas occurs after acute liver injury in rats. Also, increased levels of vitamin A in urine, saliva or plasma may be a noninvasive marker for liver injury in man after vitamin A challenge.
与用赋形剂处理的对照组相比，测定了四氯化碳诱导的急性肝损伤大鼠各种体液和组织中维生素A的分布。所有大鼠在研究前24小时腹腔注射25,000单位的视黄醇棕榈酸酯，研究当天注射50,000单位。肝损伤大鼠血浆和唾液中未酯化视黄醇显著升高，血浆、尿液和肾脏中视黄醇棕榈酸酯显著升高。此外，肝脏疾病导致肝脏中视黄醇棕榈酸酯浓度显著降低，胆汁和肾脏中未酯化视黄醇水平显著降低。这些结果表明，大鼠急性肝损伤后维生素A从肝脏重新分布到其他部位。此外，尿液、唾液或血浆中维生素A水平升高可能是人类维生素A激发后肝损伤的非侵入性标志物。
