Wang G Y, Xie Y, Zhou H F, Zhang J, Su J, Wang M X, Xu Y, Yang D
Department of Otorhinolaryngology Head and Neck Surgery,General Hospital of Tianjin Medical University,Tianjin,300052,China.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 Jul 20;30(14):1142-1145. doi: 10.13201/j.issn.1001-1781.2016.14.014.
To evaluate the value of summating potential /action potential (SP/AP) area curve ratio in diagnosis of Meniere s disease(MD) during acute attacks and quiescence phase.The normal control group and the MD group during acute attacks and quiescence phase received electrocochleography(EcochG)examination.The SP/AP amplitude and area curve ratios were measured respectively(to derive the SP/AP amplitude and area curve ratio),with normal SP/AP amplitude and area curve ratios of EcochG were identified,and analysed the results of EcochG in MD acute attacks and MD quiescence phase and the normal control group.The upper limit of normal for SP/AP amplitude and area curve ratio were respectively 0.40 and 1.78.The SP/AP area curve ratio positive rate during acute attacks was 95.56% and SP/AP amplitude ratio was 71.77%.SP/AP area curve ratio positive rate during quiescence phase was 55.56% and amplitude ratio was 33.33%.The results showed that there were significant different between the two markers(<0.05).The positive rate which during the period of acute attacks was higher than that quiescence phase period,The positive rate of the SP/AP amplitude and area curve ratios between acute attacks and quiescence phase were significant different(<0.05).By the F rest,the SP/AP area curve ratio parameters in MD acute attacks and MD quiescence phase and the normal control group were compared,and the difference was significant(=111.10,<0.05).There were significant different between the two groups among three(<0.05).The SP/AP area curve ratio parameters among the MD acute attacks and MD quiescence phase and the normal control group were significant different(=65.68,<0.05).There were significant different between the two groups among three(<0.05).It can increase the positive rate when undergo the EcochG examination during acute attacks of Meniere's disease,while the SP/AP area curve measures are more sensitive than SP/AP amplitude ratio in diagnosis of Meniere's disease.
评估总和电位/动作电位（SP/AP）面积曲线比值在梅尼埃病（MD）急性发作期及静止期诊断中的价值。对正常对照组以及MD急性发作期和静止期患者进行电耳蜗图（EcochG）检查。分别测量SP/AP振幅及面积曲线比值（得出SP/AP振幅及面积曲线比值），确定EcochG正常的SP/AP振幅及面积曲线比值，并分析MD急性发作期、MD静止期及正常对照组的EcochG结果。SP/AP振幅及面积曲线比值的正常上限分别为0.40和1.78。急性发作期SP/AP面积曲线比值阳性率为95.56%，SP/AP振幅比值为71.77%。静止期SP/AP面积曲线比值阳性率为55.56%，振幅比值为33.33%。结果显示，两种指标之间差异有统计学意义（<0.05）。急性发作期阳性率高于静止期，急性发作期与静止期SP/AP振幅及面积曲线比值阳性率差异有统计学意义（<0.05）。通过方差分析，比较MD急性发作期、MD静止期及正常对照组的SP/AP面积曲线比值参数，差异有统计学意义（F=111.10，<0.05）。三组中两组间差异有统计学意义（<0.05）。MD急性发作期、MD静止期及正常对照组的SP/AP面积曲线比值参数差异有统计学意义（F=65.68，<0.05）。三组中两组间差异有统计学意义（<0.05）。梅尼埃病急性发作期进行EcochG检查可提高阳性率，而在梅尼埃病诊断中，SP/AP面积曲线测量比SP/AP振幅比值更敏感。
