Huang X K, Yang Q T, Wang T, Wang W H, Zhang G H
Department of Otolaryngology Head and Neck Surgery， the Third Hospital Affiliated to Sun Yat-sen University, Guangzhou, 510630,China.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 Nov;30(22):1750-1753. doi: 10.13201/j.issn.1001-1781.2016.22.002.
To explore the influnces of allergen sIgE and peripheral blood eosinophilic(EOS) on the severity and surgical outcomes in patients with chronic rhinosinusitis with nasal polyps（CRSwNP）. Eighty-nine patients with CRSwNP were enrolled. Before operation, allergen sIgE levels and peripheral blood EOS were detected.All patients were examined paranasal computed tomography(CT). After 3 and 6 months of operation, all patients were examined by nasal endoscopy，Allergen sIgE, peripheral blood EOS, nasal endoscopy score, and CT score were retrospective analyzed. According to the results of allergen sIgE the subjects were divided into two groups: the positive allergens group and negative allergens group. Allergen sIgE were positive in 49 patients(the positive allergens group) and negative in 40 patients(the negative allergens group). The major allergens were Dermatophagoides pteronyssinus（39 patients） and cockroach（16 patients）. Between the positive allergens group and the allergens negative group, there were no statistically significant differences in peripheral blood EOS count and EOS percentage and CT scores and nasal endoscopy scores of 3-month postsurgery(>0.05). There was signifigant diference in the nasal endoscopy scores of 6- month postsurgery between the two groups(<0.05). In the 89 patients with CRSwNP, peripheral eosinophil count showed no significant correlation with CT image scores and 3-month postsurgery nasal endoscopy scores and 6-month postsurgery nasal endoscopy scores(=0.119，0.180，0.126，>0.05). Blood eosinophil percentage was not significantly correlated to CT image scores and 3-month postsurgery nasal endoscopy scores and 6-month postsurgery nasal endoscopy scores(=0.167，0.263，0.140，>0.05). Allergen sIgE has some impacts on postoperative outcomes but has no impact on the severity of CRSwNP. Peripheral eosinophil may not affect the severity and surgical outcomes of CRSwNP.
探讨变应原特异性免疫球蛋白E（sIgE）及外周血嗜酸性粒细胞（EOS）对慢性鼻-鼻窦炎伴鼻息肉（CRSwNP）患者病情严重程度及手术疗效的影响。纳入89例CRSwNP患者。术前检测变应原sIgE水平及外周血EOS。所有患者均行鼻窦计算机断层扫描（CT）检查。术后3个月和6个月，对所有患者进行鼻内镜检查，并对变应原sIgE、外周血EOS、鼻内镜评分及CT评分进行回顾性分析。根据变应原sIgE检测结果将研究对象分为两组：变应原阳性组和变应原阴性组。变应原sIgE阳性49例（变应原阳性组），阴性40例（变应原阴性组）。主要变应原为屋尘螨（39例）和蟑螂（16例）。变应原阳性组与变应原阴性组外周血EOS计数、EOS百分比、术后3个月CT评分及鼻内镜评分比较，差异均无统计学意义（>0.05）。两组术后6个月鼻内镜评分比较，差异有统计学意义（<0.05）。89例CRSwNP患者中，外周血嗜酸性粒细胞计数与CT图像评分、术后3个月鼻内镜评分及术后6个月鼻内镜评分均无明显相关性（=0.119、0.180、0.126，>0.05）。血嗜酸性粒细胞百分比与CT图像评分、术后3个月鼻内镜评分及术后6个月鼻内镜评分均无明显相关性（=0.167、0.263、0.140，>0.05）。变应原sIgE对术后疗效有一定影响，但对CRSwNP病情严重程度无影响。外周血嗜酸性粒细胞可能不影响CRSwNP的病情严重程度及手术疗效。
